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eIF4EBP1 protein (His tag) (ab60007)

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Overview

Product name

eIF4EBP1 protein (His tag)
See all eIF4EBP1 products (5) ...

Protein description

Recombinant full length eIF4EBP1 protein (Human), with N-terminal His tag, MW 18 kDa, expressed in insect sf9 cells.

Properties

Purity

Purified via His tag

Purification notes

Purity >95% as determined by densitometry.

Form

Liquid

Storage instructions

Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

Storage buffer

Preservative: 150mM Imidazole
Constituents: 25% Glycerol, 50mM Sodium phosphate, 300mM Sodium chloride, 0.2mM DTT, 0.1mM PMSF, pH 7.0

Concentration

Concentration information loading...

Research areas

Epigenetics and Nuclear Signaling >> RNAi >> Eukaryotic Initiation factors (eIF's)
Epigenetics and Nuclear Signaling >> DNA / RNA >> RNA Processing >> RNAi
Epigenetics and Nuclear Signaling >> DNA / RNA >> Translation >> Regulation

  • SDS-PAGE - eIF4EBP1 protein (His tag) (ab60007)SDS-PAGE - eIF4EBP1 protein (His tag) (ab60007) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab60007 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Protein info

Function

Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.

Sequence similarities

Belongs to the eIF4E-binding protein family.

Post-translational
modifications

Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-37, Thr-46, Ser-65 and Thr-70 is regulated by mTORC1. Phosphorylated upon DNA damage, probably by ATM or ATR.

Target information above from: UniProt accessionQ13541 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

eIF4EBP1 protein (His tag) images:

  SDS-PAGE - eIF4EBP1 protein (His tag) (ab60007)

SDS-PAGE - eIF4EBP1 protein (His tag) (ab60007)

ab60007 on SDS-PAGE.

References for eIF4EBP1 protein (His tag) (ab60007)

ab60007 has not yet been referenced specifically in any publications.

Publishing research using ab60007? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"