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- Secondary antibodies
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Product name
Anti-eNOS antibody
See all eNOS products (19) ...
Description
Rabbit polyclonal to eNOS
Specificity
ab23689 recognises eNOS. It does not recognise iNOS and nNOS.
Tested applications
Cross reactivity
Reacts with
Cow, Human
Immunogen
Synthetic peptide: RGAVPWAFDPPGSDTNSP conjugated to KLH, corresponding to amino acids 1186/1203 of Human eNOS.
RGAVPWAFDPPGSDTNSP
Properties
Form
Lyophilised:
Reconstitute with 100 µl of water containing 0.05% sodium azide.
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: Whole serum
Concentration
Concentration information loading...
Purity
Whole antiserum
Clonality
Polyclonal
Isotype
IgG
Research areas
Metabolism >> Types of disease >> Cancer
Metabolism >> Pathways and Processes >> Redox metabolism >> Oxidative stress
Metabolism >> Pathways and Processes >> Metabolism processes >> Hypoxia
Cancer >> Cancer Metabolism >> Response to hypoxia
Cardiovascular >> Vasculature >> Vasodilation >> Nitric oxide associated
Cell Biology >> Other Antibodies >> Oxidative Stress
Cardiovascular >> Blood >> Platelets
Neuroscience >> Neurotransmission >> Nitric Oxide >> NOS
Applications
Show applications key
Our Abpromise guarantee covers the use of ab23689 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/1000 - 1/2000. Predicted molecular weight: 135 kDa.
Target
Function
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
Tissue specificity
Platelets, placenta, liver and kidney.
Sequence similarities
Belongs to the NOS family.
Contains 1 FAD-binding FR-type domain.
Contains 1 flavodoxin-like domain.
Cellular localization
Cell membrane. Membrane > caveola. Cytoplasm > cytoskeleton. Golgi apparatus. Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle and which is favored by interaction with NOSIP and results in a reduced enzymatic activity.
Target information above from: UniProt accessionP29474
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- cNOS antibody
- Constitutive NOS antibody
- EC NOS antibody
see all
Database links
- Entrez Gene: 287024 Cow
- Entrez Gene: 4846 Human
- Omim: 163729 Human
- SwissProt: P29473 Cow
- SwissProt: P29474 Human
- Unigene: 647092 Human
References for Anti-eNOS antibody (ab23689)
ab23689 has not yet been referenced specifically in any publications.
Publishing research using ab23689? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"