Overview

  • Product name
  • Description
    Goat polyclonal to EAAT1
  • Host species
    Goat
  • Specificity
    ab166937 is expected to recognize isoform 1 (NP_004163.3) and isoform 2 (NP_001160167.1).
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide with a Cysteine residue linker, corresponding to C terminal amino acids 529-541 (isoform 1) and 484-496 (isoform 2) of Human EAAT1 (NP_004163.3; NP_001160167.1).

  • Positive control
    • Human Brain (Hippocampus) lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab166937 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 55, 60 kDa.

Target

  • Function
    Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.
  • Tissue specificity
    Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia.
  • Involvement in disease
    Defects in SLC1A3 are the cause of episodic ataxia type 6 (EA6) [MIM:612656]. EA6 is characterized by episodic ataxia, seizures, migraine and alternating hemiplegia.
  • Sequence similarities
    Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A3 subfamily.
  • Post-translational
    modifications
    Glycosylated.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • EA6 antibody
    • EAA1_HUMAN antibody
    • EAAT1 antibody
    • Excitatory amino acid transporter 1 antibody
    • FLJ25094 antibody
    • GLAST antibody
    • GLAST-1 antibody
    • GLAST1 antibody
    • Glial high affinity glutamate transporter antibody
    • glutamate/aspartate transporter, high affinity, sodium-dependent antibody
    • High affinity neuronal glutamate transporter antibody
    • Slc1a3 antibody
    • Sodium dependent glutamate/aspartate transporter antibody
    • Sodium-dependent glutamate/aspartate transporter 1 antibody
    • Solute carrier family 1 (glial high affinity glutamate transporter) member 3 antibody
    • Solute carrier family 1 member 3 antibody
    see all

Images

  • Anti-EAAT1 antibody (ab166937) at 2 µg/ml + Human Brain (Hippocampus) lysate (in RIPA buffer) at 35 µg

    Developed using the ECL technique.

    Predicted band size: 55, 60 kDa

References

ab166937 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab166937.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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