FunctionMay be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.
Tissue specificityExpressed in different tumor cell lines. Up-regulated in activated B- and T-lymphocytes.
Sequence similaritiesBelongs to the MAPRE family. Contains 1 CH (calponin-homology) domain. Contains 1 EB1 C-terminal domain.
DomainComposed of two functionally independent domains. The N-terminal domain forms an hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.
Cellular localizationCytoplasm > cytoskeleton. Associated with the microtubule network. Accumulates at the plus end of microtubules.
H.sapiens mRNA for novel T cell activation protein antibody
Microtubule associated protein RP/EB family member 2 antibody
Microtubule-associated protein RP/EB family member 2 antibody
T cell activation protein EB1 family antibody
Anti-EB2 antibody images
Western blot - Anti-EB2 antibody (ab123579)
Anti-EB2 antibody (ab123579) at 1/100 dilution + CEM cell line lysate at 35 µg
Predicted band size : 37 kDa
References for Anti-EB2 antibody (ab123579)
This product has been referenced in:
Nakamura S et al. Dissecting the nanoscale distributions and functions of microtubule-end-binding proteins EB1 and ch-TOG in interphase HeLa cells. PLoS One7:e51442 (2012).
Read more (PubMed: 23251535) »