Overview

  • Product name
    Anti-EBI3 antibody (Biotin)
    See all EBI3 primary antibodies
  • Description
    Rabbit polyclonal to EBI3 (Biotin)
  • Conjugation
    Biotin
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat
    Does not react with: Human
  • Immunogen

    Recombinant full length Mouse EBI3 protein.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    pH: 7.20
    Preservative: 0.01% Sodium azide
    Constituents: 0.42% Potassium phosphate, 0.88% Sodium chloride, 1% BSA
  • Concentration information loading...
  • Purity
    IgG fraction
  • Purification notes
    ab106031 is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab106031 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2000 - 1/10000. Detects a band of approximately 23 kDa (predicted molecular weight: 25 kDa).

Target

  • Function
    Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.
  • Sequence similarities
    Belongs to the type I cytokine receptor family. Type 3 subfamily.
    Contains 2 fibronectin type-III domains.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • cytokine receptor antibody
    • EBI3 antibody
    • EBV induced gene 3 protein antibody
    • EBV-induced gene 3 protein antibody
    • Epstein Barr virus induced 3 antibody
    • Epstein Barr virus induced gene 3 antibody
    • Epstein Barr virus induced gene 3 protein antibody
    • Epstein-Barr virus-induced gene 3 protein antibody
    • IL 27 subunit beta antibody
    • IL 27B antibody
    • IL-27 subunit beta antibody
    • IL-27B antibody
    • IL27 subunit antibody
    • IL27 subunit beta antibody
    • IL27B antibody
    • IL27B_HUMAN antibody
    • IL35 subunit antibody
    • interleukin 27 subunit beta antibody
    • Interleukin-27 subunit beta antibody
    see all

Images

  • Anti-EBI3 antibody (Biotin) (ab106031) at 1/2000 dilution + Mouse cell extract

    Predicted band size : 25 kDa

References

ab106031 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab106031.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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