Anti-EBNA 3C antibody (ab16128)
Key features and details
- Sheep polyclonal to EBNA 3C
- Suitable for: ELISA, ICC/IF, IHC-Fr
- Isotype: IgG
Overview
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Product name
Anti-EBNA 3C antibody -
Description
Sheep polyclonal to EBNA 3C -
Host species
Sheep -
Specificity
This antibody is specific for the Epstein Barr Virus Nuclear Antigen 3C. -
Tested applications
Suitable for: ELISA, ICC/IF, IHC-Frmore details -
Species reactivity
Reacts with: Epstein-Barr virus -
Immunogen
Recombinant full length protein corresponding to Epstein-Barr virus EBNA 3C.
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General notes
EBNA 3C is a latent viral nuclear protein expressed in EBV transformed lymphoblastic cell lines and is essential for EBV mediated transformation of these cell lines. This viral nuclear protein is essential for EBV mediated positive immunoblastic lymphomas, and functions as a transcription factor.
Source: Sheep were immunized with recombinant EBNA-3C protein
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.08% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Ammonium Sulphate Precipitation -
Purification notes
Purified by ammonium sulfate precipitation This antibody is provided as a 0.2µm sterile filtered solution. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab16128 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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ELISA |
Use at an assay dependent concentration.
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ICC/IF |
Use at an assay dependent concentration.
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IHC-Fr |
Use at an assay dependent concentration.
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Notes |
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ELISA
Use at an assay dependent concentration. |
ICC/IF
Use at an assay dependent concentration. |
IHC-Fr
Use at an assay dependent concentration. |
Target
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Relevance
EBNA 3C is a latent viral nuclear protein expressed in EBV transformed lymphoblastic cell lines and is essential for EBV mediated transformation of these cell lines. This viral nuclear protein is essential for EBV mediated positive immunoblastic lymphomas, and functions as a transcription factor. -
Database links
- SwissProt: P03204 Epstein-Barr virus
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Alternative names
- EBNA 3C antibody
- EBNA 4B antibody
- EBNA 6 antibody
see all
Datasheets and documents
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Datasheet download
References (8)
ab16128 has been referenced in 8 publications.
- Gain C et al. Proteasomal inhibition triggers viral oncoprotein degradation via autophagy-lysosomal pathway. PLoS Pathog 16:e1008105 (2020). PubMed: 32092124
- Wang LW et al. Epstein-Barr virus subverts mevalonate and fatty acid pathways to promote infected B-cell proliferation and survival. PLoS Pathog 15:e1008030 (2019). PubMed: 31518366
- Bhattacharjee S et al. Transcriptional and epigenetic modulation of autophagy promotes EBV oncoprotein EBNA3C induced B-cell survival. Cell Death Dis 9:605 (2018). PubMed: 29789559
- Gillman ACT et al. Epstein-Barr Virus Nuclear Antigen 3C Inhibits Expression of COBLL1 and the ADAM28-ADAMDEC1 Locus via Interaction with the Histone Lysine Demethylase KDM2B. J Virol 92:N/A (2018). PubMed: 30135119
- Siouda M et al. Epstein-Barr virus down-regulates tumor suppressor DOK1 expression. PLoS Pathog 10:e1004125 (2014). WB . PubMed: 24809689
- McClellan MJ et al. Modulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs cellular reprogramming. PLoS Pathog 9:e1003636 (2013). ChIP-sequencing . PubMed: 24068937
- McClellan MJ et al. Downregulation of Integrin Receptor-Signaling Genes by Epstein-Barr Virus EBNA 3C via Promoter-Proximal and -Distal Binding Elements. J Virol 86:5165-78 (2012). ChIP . PubMed: 22357270
- Sun X et al. Hsp90 inhibitors block outgrowth of EBV-infected malignant cells in vitro and in vivo through an EBNA1-dependent mechanism. Proc Natl Acad Sci U S A 107:3146-51 (2010). WB . PubMed: 20133771