Biological descriptionPhotostable synthetic retinoid. All-trans retinoic acid (ATRA) (ab120728) analog. Displays similar biological activity to ATRA. Potently induces stem cell differentiation and enables improved consistency of neuronal differentiation. Induces neurogenesis.
Chemical name4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl]benzoic acid
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 50 mM and in ethanol to 10 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Christie VB et al. Retinoid supplementation of differentiating human neural progenitors and embryonic stem cells leads to enhanced neurogenesis in vitro. J Neurosci Methods193:239-45 (2010).
Read more (PubMed: 20817032) »
Maltman DJ et al. Proteomic profiling of the stem cell response to retinoic acid and synthetic retinoid analogues: identification of major retinoid-inducible proteins. Mol Biosyst5:458-71 (2009).
Read more (PubMed: 19381361) »