RelevanceThe protein encoded by this gene is a transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis.
Cellular localizationECT2 exhibits nuclear localization in interphase, spreads throughout the cytoplasm in prometaphase, and is condensed in the midbody during cytokinesis
Epithelial cell transforming sequence 2 oncogene protein antibody
Anti-ECT2 antibody images
Western blot - Anti-ECT2 antibody (ab123571)
Anti-ECT2 antibody (ab123571) at 1/100 dilution + 293 cell lysate at 35 µg
Predicted band size : 100 kDa
References for Anti-ECT2 antibody (ab123571)
This product has been referenced in:
Xie J et al. Small interfering RNA-induced inhibition of epithelial cell transforming sequence 2 suppresses the proliferation, migration and invasion of osteosarcoma cells. Exp Ther Med9:1881-1886 (2015).
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