Anti-EDA antibody - Aminoterminal end (ab64748)

Overview

  • Product nameAnti-EDA antibody - Aminoterminal end
    See all EDA primary antibodies
  • Description
    Rabbit polyclonal to EDA - Aminoterminal end
  • SpecificityThis antibody reacts with EDA
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    This information is considered to be commercially sensitive.

  • Positive control
    • Hela cell line lysates

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab64748 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/50 - 1/100. Detects a band of approximately 42 kDa (predicted molecular weight: 42 kDa).
ELISA 1/1000.

Target

  • FunctionSeems to be involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Isoform 1 binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor XEDAR.
  • Tissue specificityNot abundant; expressed in specific cell types of ectodermal (but not mesodermal) origin of keratinocytes, hair follicles, sweat glands. Also in adult heart, liver, muscle, pancreas, prostate, fetal liver, uterus, small intestine and umbilical chord.
  • Involvement in diseaseDefects in EDA are the cause of ectodermal dysplasia type 1 (ED1) [MIM:305100]; also known as Christ-Siemens-Touraine syndrome or X-linked hypohidrotic ectodermal dysplasia (XLHED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. ED1 is a disease characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. ED1 is the most common form of over 150 clinically distinct ectodermal dysplasias.
    Defects in EDA are the cause of tooth agenesis selective X-linked type 1 (STHAGX1) [MIM:313500]. A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth).
  • Sequence similaritiesBelongs to the tumor necrosis factor family.
    Contains 1 collagen-like domain.
  • Post-translational
    modifications
    N-glycosylated.
    Processing by furin produces a secreted form.
  • Cellular localizationSecreted and Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • ECTD1 antibody
    • Ectodermal dysplasia 1, anhidrotic antibody
    • Ectodermal dysplasia protein antibody
    • Ectodermal dysplasia, anhidrotic (hypohydrotic) antibody
    • Ectodysplasin A antibody
    • Ectodysplasin A, membrane form antibody
    • Ectodysplasin A, secreted form antibody
    • ECTODYSPLASIN A1 ISOFORM antibody
    • ECTODYSPLASIN A2 ISOFORM antibody
    • ECTODYSPLASIN antibody
    • Ectodysplasin-A antibody
    • ED1 A1 antibody
    • ED1 A2 antibody
    • ED1 antibody
    • ED1 GENE antibody
    • Eda A1 antibody
    • Eda A2 antibody
    • eda antibody
    • EDA protein antibody
    • EDA protein homolog antibody
    • EDA_HUMAN antibody
    • EDA1 antibody
    • EDA1 GENE antibody
    • EDA2 antibody
    • HED antibody
    • HED1 antibody
    • ODT1 antibody
    • Oligodontia 1 antibody
    • secreted form antibody
    • STHAGX1 antibody
    • Ta antibody
    • Tabby antibody
    • Tabby protein antibody
    • X linked anhidroitic ectodermal dysplasia protein antibody
    • XHED antibody
    • XLHED antibody
    see all

Anti-EDA antibody - Aminoterminal end images

  • Anti-EDA antibody - Aminoterminal end (ab64748) at 1/60 dilution + Hela cell line lysates at 35 µg

    Predicted band size : 42 kDa
    Observed band size : 42 kDa

References for Anti-EDA antibody - Aminoterminal end (ab64748)

ab64748 has not yet been referenced specifically in any publications.

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