Overview

  • Product nameAnti-EDC4 antibody
    See all EDC4 primary antibodies
  • Description
    Mouse monoclonal to EDC4
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment: PAQVFGQPPC PLSQPVLLSL IQQLASDLGT RTDLKLSYLE EAVMHLDHSD PITRDHMGSV MAQVRQKLFQ FLQAEPHNSL GKAARRLSLM LHGLVTPSLP, corresponding to C terminal amino acids 1302 - 1401 of Human EDC4 with a proprietary tag (NP_055144).

  • Positive control
    • Human tonsil tissue

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage bufferpH: 7.20
    Constituent: 99% PBS
  • Concentration information loading...
  • PurityProtein A purified
  • ClonalityMonoclonal
  • IsotypeIgG2a
  • Light chain typekappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab118323 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3 µg/ml. Antigen retrieval is not essential but may optimise staining. Place sample in 1X citrate buffer (pH 6.0) in pressure cooker under 125 °C for 4min and under 90 °C for 45min, cool sample subsequently.

Target

  • FunctionIn the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro).
  • Sequence similaritiesBelongs to the WD repeat EDC4 family.
    Contains 4 WD repeats.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationCytoplasm > P-body. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • autoantigen antibody
    • Autoantigen Ge 1 antibody
    • Autoantigen Ge-1 antibody
    • Autoantigen Ge1 antibody
    • Autoantigen RCD 8 antibody
    • Autoantigen RCD-8 antibody
    • Autoantigen RCD8 antibody
    • edc4 antibody
    • EDC4_HUMAN antibody
    • Enhancer of mRNA decapping 4 antibody
    • Enhancer of mRNA-decapping protein 4 antibody
    • Ge 1 antibody
    • Hedls antibody
    • Human enhancer of decapping large subunit antibody
    • RCD 8 antibody
    see all

Anti-EDC4 antibody images

  • ab118323, at 3 ug/ml, staining EDC4 in formalin-fixed, paraffin-embedded Human tonsil tissue by Immunohistochemistry.

References for Anti-EDC4 antibody (ab118323)

ab118323 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"