Overview

  • Product nameAnti-EDD antibody
    See all EDD primary antibodies
  • Description
    Rabbit polyclonal to EDD
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Horse, Chicken, Cow, Dog, Turkey, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Xenopus tropicalis , Platypus (Ornithorhynchus anatinus)
  • Immunogen

    Synthetic peptide corresponding to a region between residues 600 and 650 of human (NP_056986.2)

  • Positive control
    • Human breast adenocarcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab84135 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notesIHC-P: 1/100 - 1/500.
    Epitope exposure with citrate buffer will enhance staining.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionE3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific amino-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). May be involved in maturation and/or transcriptional regulation of mRNA. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development.
    • Tissue specificityWidely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney.
    • PathwayProtein modification; protein ubiquitination.
    • Sequence similaritiesContains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
      Contains 1 PABC domain.
      Contains 1 UBR-type zinc finger.
    • Post-translational
      modifications
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • 4432411E13Rik antibody
      • AW549941 antibody
      • C77315 antibody
      • D030042K14 antibody
      • DD5 antibody
      • E3 identified by differential display antibody
      • E3 ubiquitin protein ligase, HECT domain containing, 1 antibody
      • E3 ubiquitin-protein ligase antibody
      • E3 ubiquitin-protein ligase UBR5 antibody
      • EDD 1 antibody
      • EDD antibody
      • EDD1 antibody
      • FLJ11310 antibody
      • HECT domain-containing 1 antibody
      • hHYD antibody
      • HYD antibody
      • Hyperplastic discs protein homolog antibody
      • Hyperplastic discs, Drosophila, homolog of antibody
      • KIAA0896 antibody
      • MGC57263 antibody
      • mKIAA0896 antibody
      • Progestin induced protein antibody
      • Progestin-induced protein antibody
      • Rat100 antibody
      • Ubiquitin protein ligase antibody
      • Ubiquitin protein ligase E3 component n recognin 5 antibody
      • UBR5 antibody
      • UBR5_HUMAN antibody
      see all

    Anti-EDD antibody images

    • ab84135 at 1/100 dilution staining EDD in human breast adenocarcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.

    References for Anti-EDD antibody (ab84135)

    ab84135 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab84135.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"