Overview

  • Product name
  • Description
    Goat polyclonal to EDF1
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide: AESDWDTVTVLRK-C, corresponding to amino acids 2-14 of Human EDF1 (NP_003783.1).

  • Positive control
    • Human Brain, Cortex and Pancreas tissues

Properties

Applications

Our Abpromise guarantee covers the use of ab118583 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3.75 - 7.5 µg/ml.

Target

  • Function
    Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.
  • Tissue specificity
    Expressed in brain, liver, lung, kidney and heart (at protein level). Ubiquitously expressed. More abundant in heart, pancreas, liver, intestine and adipose tissues.
  • Sequence similarities
    Contains 1 HTH cro/C1-type DNA-binding domain.
  • Developmental stage
    Expressed in fetal tissues. More abundant in kidney.
  • Domain
    The IQ motif, which is involved in calmodulin binding, overlaps with the binding domain for nuclear receptors and transcription factors. Its phosphorylation probably allows a switch between the two activities of the protein.
  • Post-translational
    modifications
    Phosphorylated (by PKA and PKC).
  • Cellular localization
    Cytoplasm. Nucleus. Also nuclear upon binding to NR5A1 and treatment of cells with TPA or forskolin.
  • Information by UniProt
  • Database links
  • Alternative names
    • CAP19 antibody
    • EDF-1 antibody
    • edf1 antibody
    • EDF1_HUMAN antibody
    • Endothelial differentiation related factor 1 antibody
    • Endothelial differentiation-related factor 1 antibody
    • MBF1 antibody
    • MGC9058 antibody
    • Multiprotein bridging factor 1 antibody
    • Multiprotein-bridging factor 1 antibody
    see all

Images

  • ab118583, at 7.5 µg/ml, staining EDF1 in formalin-fixed, paraffin-embedded Human Brain, Cortex tissue by Immunohistochemistry.
  • ab118583, at 7.5 µg/ml, staining EDF1 in formalin-fixed, paraffin-embedded Human Pancreas tissue by Immunohistochemistry.

References

ab118583 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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