The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/50 - 1/100.
FunctionReceptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. This inducible epithelial cell G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells. Seems to be coupled to the G(i) subclass of heteromeric G proteins.
Tissue specificityEndothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
Post-translational modificationsS1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third intracellular loop at the Thr-236 residue.
ab60038 at 1/50 dilution staining EDG1 in Human breast carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue.
A peroxidase-conjugated secondary antibody was used, followed by AEC staining.
References for Anti-EDG1 antibody - Aminoterminal end (ab60038)
has not yet been referenced specifically in any publications.
Publishing research using ab60038? Please let us know so that we can cite the reference in this datasheet.
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