Application notesIs unsuitable for Flow Cyt,ICC,IHC-P or IP.
FunctionReceptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. This inducible epithelial cell G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells. Seems to be coupled to the G(i) subclass of heteromeric G proteins.
Tissue specificityEndothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
Post-translational modificationsS1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third intracellular loop at the Thr-236 residue.
Sphingosine 1phosphate receptor type 1 S1P1 antibody
Anti-EDG1 antibody [EPR4538(2)] images
Western blot - Anti-EDG1 antibody [EPR4538(2)] (ab125074)
All lanes : Anti-EDG1 antibody [EPR4538(2)] (ab125074) at 1/10000 dilution
Lane 1 : Jurkat cell lysate Lane 2 : SH-SY5Y cell lysate Lane 3 : HUVEC cell lysate Lane 4 : A375 cell lysate
Lysates/proteins at 10 µg per lane.
Predicted band size : 43 kDa
References for Anti-EDG1 antibody [EPR4538(2)] (ab125074)
This product has been referenced in:
Arana L et al. Ceramide 1-phosphate induces macrophage chemoattractant protein-1 release: involvement in ceramide 1-phosphate-stimulated cell migration. Am J Physiol Endocrinol Metab304:E1213-26 (2013).
Read more (PubMed: 23548612) »
Goyal P et al. Cytokine IL-6 secretion by trophoblasts regulated via sphingosine-1-phosphate receptor 2 involving Rho/Rho-kinase and Rac1 signaling pathways. Mol Hum Reprod19:528-38 (2013).
Read more (PubMed: 23538947) »