Overview

  • Product nameAnti-EDG1 antibody [EPR4538(2)]
    See all EDG1 primary antibodies
  • Description
    Rabbit monoclonal [EPR4538(2)] to EDG1
  • Tested applicationsSuitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC,IHC-P or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) corresponding to Human EDG1 aa 1-100 (N terminal).

  • Positive control
    • Jurkat, SH-SY5Y, HUVEC and A375 cell lysates.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab125074 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/10000 - 1/50000. Predicted molecular weight: 43 kDa.
  • Application notesIs unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • Target

    • FunctionReceptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. This inducible epithelial cell G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells. Seems to be coupled to the G(i) subclass of heteromeric G proteins.
    • Tissue specificityEndothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin.
    • Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
    • Post-translational
      modifications
      S1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third intracellular loop at the Thr-236 residue.
    • Cellular localizationCell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • CD363 antibody
      • CHEDG 1 antibody
      • CHEDG1 antibody
      • D1S3362 antibody
      • ECGF 1 antibody
      • ECGF1 antibody
      • EDG 1 antibody
      • EDG1 antibody
      • endothelial differentiation G protein coupled receptor 1 antibody
      • Endothelial differentiation G-protein coupled receptor 1 antibody
      • Endothelial differentiation sphingolipid G protein coupled receptor 1 antibody
      • FLJ58121 antibody
      • G protein coupled sphingolipid receptor antibody
      • g protein-coupled receptor edg-1 antibody
      • S1P receptor 1 antibody
      • S1P receptor Edg 1 antibody
      • S1P receptor Edg-1 antibody
      • S1P receptor Edg1 antibody
      • S1P(1) receptor antibody
      • S1P1 antibody
      • s1pr1 antibody
      • S1PR1_HUMAN antibody
      • sphingolipid g-protein-coupled receptor 1 antibody
      • Sphingosine 1 phosphate receptor Edg 1 antibody
      • Sphingosine 1 phosphate receptor EDG1 antibody
      • sphingosine 1- phosphate receptor 1 antibody
      • Sphingosine 1-phosphate receptor 1 antibody
      • Sphingosine 1-phosphate receptor Edg-1 antibody
      • Sphingosine 1phosphate receptor type 1 S1P1 antibody
      see all

    Anti-EDG1 antibody [EPR4538(2)] images

    • All lanes : Anti-EDG1 antibody [EPR4538(2)] (ab125074) at 1/10000 dilution

      Lane 1 : Jurkat cell lysate
      Lane 2 : SH-SY5Y cell lysate
      Lane 3 : HUVEC cell lysate
      Lane 4 : A375 cell lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 43 kDa

    References for Anti-EDG1 antibody [EPR4538(2)] (ab125074)

    This product has been referenced in:
    • Arana L  et al. Ceramide 1-phosphate induces macrophage chemoattractant protein-1 release: involvement in ceramide 1-phosphate-stimulated cell migration. Am J Physiol Endocrinol Metab 304:E1213-26 (2013). Read more (PubMed: 23548612) »
    • Goyal P  et al. Cytokine IL-6 secretion by trophoblasts regulated via sphingosine-1-phosphate receptor 2 involving Rho/Rho-kinase and Rac1 signaling pathways. Mol Hum Reprod 19:528-38 (2013). Read more (PubMed: 23538947) »

    See all 2 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"