The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/10000 - 1/50000. Detects a band of approximately 42 kDa (predicted molecular weight: 42 kDa).
Application notesIs unsuitable for Flow Cyt,ICC,IHC-P or IP.
FunctionReceptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.
Tissue specificityExpressed in all tissues, but most abundantly in heart, placenta, kidney, and liver.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.