Overview

  • Product name
    Anti-EDG3 antibody [EPR4540(2)]
    See all EDG3 primary antibodies
  • Description
    Rabbit monoclonal [EPR4540(2)] to EDG3
  • Tested applications
    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC,IHC-P or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) corresponding to Human EDG3 aa 1-100 (N terminal).

  • Positive control
    • MCF-7 cell lysate, HepG2 cell lysate, 293T cell lysate, JAR cell lysate.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

Properties

Applications

Our Abpromise guarantee covers the use of ab108370 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/10000 - 1/50000. Detects a band of approximately 42 kDa (predicted molecular weight: 42 kDa).
  • Application notes
    Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • Target

    • Function
      Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.
    • Tissue specificity
      Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver.
    • Sequence similarities
      Belongs to the G-protein coupled receptor 1 family.
    • Cellular localization
      Cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • EDG 3 antibody
      • EDG3 antibody
      • Endothelial differentiation G protein coupled receptor 3 antibody
      • Endothelial differentiation G-protein coupled receptor 3 antibody
      • Endothelial differentiation gene 3 antibody
      • Endothelial differentiation sphingolipid G protein coupled receptor 3 antibody
      • FLJ37523 antibody
      • FLJ93220 antibody
      • G protein coupled receptor endothelial differentiation gene 3 antibody
      • LPB 3 antibody
      • LPB3 antibody
      • MGC71696 antibody
      • OTTHUMP00000215691 antibody
      • S1P receptor 3 antibody
      • S1P receptor Edg 3 antibody
      • S1P receptor Edg-3 antibody
      • S1P receptor EDG3 antibody
      • S1P3 antibody
      • S1pr3 antibody
      • S1PR3_HUMAN antibody
      • Sphingosine 1 phosphate receptor 3 antibody
      • Sphingosine 1 phosphate receptor Edg 3 antibody
      • Sphingosine 1 phosphate receptor Edg3 antibody
      • Sphingosine 1-phosphate receptor 3 antibody
      • Sphingosine 1-phosphate receptor Edg-3 antibody
      see all

    Images

    • All lanes : Anti-EDG3 antibody [EPR4540(2)] (ab108370) at 1/10000 dilution

      Lane 1 : MCF-7 cell lysate
      Lane 2 : HepG2 cell lysate
      Lane 3 : 293T cell lysate
      Lane 4 : JAR cell lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 42 kDa

    References

    This product has been referenced in:
    • Guan Z  et al. Sphingosine-1-Phosphate Evokes Unique Segment-Specific Vasoconstriction of the Renal Microvasculature. J Am Soc Nephrol N/A:N/A (2014). Read more (PubMed: 24578134) »
    • Arana L  et al. Ceramide 1-phosphate induces macrophage chemoattractant protein-1 release: involvement in ceramide 1-phosphate-stimulated cell migration. Am J Physiol Endocrinol Metab 304:E1213-26 (2013). Read more (PubMed: 23548612) »

    See all 3 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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