Anti-EDG8 antibody - Aminoterminal end (ab60039)

Overview

  • Product nameAnti-EDG8 antibody - Aminoterminal end
    See all EDG8 primary antibodies
  • Description
    Rabbit polyclonal to EDG8 - Aminoterminal end
  • Tested applicationsSuitable for: ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide (10-30 aa in length) at the N-terminal of first 50 aa of human EDG8 conjugated to KLH

  • Positive control
    • Human hepatocarcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab60039 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
IHC-P 1/50 - 1/100.

Target

  • FunctionReceptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.
  • Tissue specificityWidely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts. Overexpressed in leukemic large granular lymphocytes. Isoform 1 is predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood leukocytes.
  • Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
  • Developmental stageAt 24 weeks of gestation, fragments of radial glial fibers are positive within the cortical plate and subplate of allocortical areas. These positive fragments often appear enlarged as varicosities and some of them terminate at blood vessels. Between 28 and 30 weeks of gestation, all iso- and allocortical areas contain immunolabelled radial glial fibers revealing curvature next to sulci. After 32 weeks of gestation, radial glial fibers gradually disappear; instead positive transitional stages between radial glia and astrocytes were found.
  • Cellular localizationCell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • EDG 8 antibody
    • EDG8 S1P receptor antibody
    • Endothelial differentiation G protein coupled receptor 8 antibody
    • Endothelial differentiation G-protein-coupled receptor 8 antibody
    • Endothelial Differentiation Gene 8 antibody
    • Endothelial differentiation sphingolipid G protein coupled receptor 8 antibody
    • S1P receptor 5 antibody
    • S1P receptor Edg 8 antibody
    • S1P receptor Edg-8 antibody
    • S1P receptor Edg8 antibody
    • S1P5 antibody
    • S1PR5 antibody
    • S1PR5_HUMAN antibody
    • Sphingosine 1 Phosphate Receptor 5 antibody
    • Sphingosine 1 phosphate receptor Edg 8 antibody
    • Sphingosine 1 phosphate receptor Edg8 antibody
    • Sphingosine 1-phosphate receptor 5 antibody
    • Sphingosine 1-phosphate receptor Edg-8 antibody
    • SPPR 1 antibody
    • SPPR 2 antibody
    • SPPR1 antibody
    • SPPR2 antibody
    see all

Anti-EDG8 antibody - Aminoterminal end images

  • ab60039 at 1/50 dilution staining EDG8 in Human hepatocarcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. A peroxidase-conjugated secondary antibody was used, followed by AEC staining.

References for Anti-EDG8 antibody - Aminoterminal end (ab60039)

ab60039 has not yet been referenced specifically in any publications.

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