Anti-EEA1 antibody - Early Endosome Marker (ab2900)

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ab2900 has been referenced in 112 publications.

  • Kleinecke S  et al. Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy. Elife 6:N/A (2017). IF ; Mouse . PubMed: 28470148
  • Verzeaux L  et al. Intrinsic dynamics study identifies two amino acids of TIMP-1 critical for its LRP-1-mediated endocytosis in neurons. Sci Rep 7:5375 (2017). ICC/IF ; Mouse . PubMed: 28710453
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  • Bartuzi P  et al. CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL. Nat Commun 7:10961 (2016). PubMed: 26965651
  • Liu J  et al. ATP-containing vesicles in stria vascular marginal cell cytoplasms in neonatal rat cochlea are lysosomes. Sci Rep 6:20903 (2016). PubMed: 26864824
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  • Wahl S  et al. The Disease Protein Tulp1 Is Essential for Periactive Zone Endocytosis in Photoreceptor Ribbon Synapses. J Neurosci 36:2473-93 (2016). PubMed: 26911694
  • Clifford RJ  et al. Dynamic internalization and recycling of a metal ion transporter: Cu homeostasis and CTR1, the human Cu? uptake system. J Cell Sci 129:1711-21 (2016). PubMed: 26945057
  • Chen Y  et al. Caenorhabditis elegans paraoxonase-like proteins control the functional expression of DEG/ENaC mechanosensory proteins. Mol Biol Cell 27:1272-85 (2016). IF . PubMed: 26941331
  • Ortiz DA  et al. Protein-Protein Interactions Suggest Novel Activities of Human Cytomegalovirus Tegument Protein pUL103. J Virol 90:7798-810 (2016). WB, ICC/IF ; Human . PubMed: 27334581
  • Albert V  et al. mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue. EMBO Mol Med 8:232-46 (2016). WB ; Mouse . PubMed: 26772600
  • Gelis L  et al. Functional Characterization of the Odorant Receptor 51E2 in Human Melanocytes. J Biol Chem 291:17772-86 (2016). PubMed: 27226631
  • Kaur I  et al. Activity-Dependent Palmitoylation Controls SynDIG1 Stability, Localization, and Function. J Neurosci 36:7562-8 (2016). PubMed: 27445135
  • Martinez H  et al. Spatial-Temporal Study of Rab1b Dynamics and Function at the ER-Golgi Interface. PLoS One 11:e0160838 (2016). PubMed: 27500526
  • Cañas MA  et al. Outer Membrane Vesicles from the Probiotic Escherichia coli Nissle 1917 and the Commensal ECOR12 Enter Intestinal Epithelial Cells via Clathrin-Dependent Endocytosis and Elicit Differential Effects on DNA Damage. PLoS One 11:e0160374 (2016). ICC/IF ; Human . PubMed: 27487076
  • Bround MJ  et al. Cardiac Ryanodine Receptor (Ryr2)-mediated Calcium Signals Specifically Promote Glucose Oxidation via Pyruvate Dehydrogenase. J Biol Chem 291:23490-23505 (2016). PubMed: 27621312
  • Doherty CM  et al. Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity. J Biol Chem 291:22160-22172 (2016). PubMed: 27582494
  • Xiong L  et al. Retromer in Osteoblasts Interacts With Protein Phosphatase 1 Regulator Subunit 14C, Terminates Parathyroid Hormone's Signaling, and Promotes Its Catabolic Response. EBioMedicine 9:45-60 (2016). PubMed: 27333042
  • Bourseau-Guilmain E  et al. Hypoxia regulates global membrane protein endocytosis through caveolin-1 in cancer cells. Nat Commun 7:11371 (2016). WB, IHC-Fr, ICC/IF . PubMed: 27094744
  • Raha AA  et al. Neuroprotective Effect of TREM-2 in Aging and Alzheimer's Disease Model. J Alzheimers Dis N/A:N/A (2016). IHC ; Mouse . PubMed: 27662313
  • Hutten TJ  et al. CLEC12A-Mediated Antigen Uptake and Cross-Presentation by Human Dendritic Cell Subsets Efficiently Boost Tumor-Reactive T Cell Responses. J Immunol 197:2715-25 (2016). PubMed: 27566820
  • Chanduri M  et al. Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transport. Biochem J 473:3031-47 (2016). PubMed: 27474409
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  • Da Ros M  et al. Retromer vesicles interact with RNA granules in haploid male germ cells. Mol Cell Endocrinol 401:73-83 (2015). PubMed: 25486514
  • Zeineddine R  et al. SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation. Mol Neurodegener 10:57 (2015). Mouse . PubMed: 26520394
  • Zhou Y  et al. Chitinase 3-like-1 and its receptors in Hermansky-Pudlak syndrome-associated lung disease. J Clin Invest 125:3178-92 (2015). PubMed: 26121745
  • Camorani S  et al. Aptamer targeting EGFRvIII mutant hampers its constitutive autophosphorylation and affects migration, invasion and proliferation of glioblastoma cells. Oncotarget 6:37570-87 (2015). PubMed: 26461476
  • Mrschtik M  et al. DRAM-3 modulates autophagy and promotes cell survival in the absence of glucose. Cell Death Differ 22:1714-26 (2015). PubMed: 25929859
  • Santiago-Tirado FH  et al. A Single Protein S-acyl Transferase Acts through Diverse Substrates to Determine Cryptococcal Morphology, Stress Tolerance, and Pathogenic Outcome. PLoS Pathog 11:e1004908 (2015). PubMed: 25970403
  • Zhao J & Hedera P Strumpellin and Spartin, Hereditary Spastic Paraplegia Proteins, are Binding Partners. J Exp Neurosci 9:15-25 (2015). ICC . PubMed: 25987849
  • Zhao L  et al. Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration. EMBO Mol Med 7:1179-97 (2015). IHC . PubMed: 26139610
  • Lo Cicero A  et al. Exosomes released by keratinocytes modulate melanocyte pigmentation. Nat Commun 6:7506 (2015). PubMed: 26103923
  • Satoh K  et al. ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing. J Biol Chem 290:24152-65 (2015). PubMed: 26260791
  • Yeganeh B  et al. Suppression of influenza A virus replication in human lung epithelial cells by noncytotoxic concentrations bafilomycin A1. Am J Physiol Lung Cell Mol Physiol 308:L270-86 (2015). PubMed: 25361566
  • Jahic A  et al. The spectrum of KIAA0196 variants, and characterization of a murine knockout: implications for the mutational mechanism in hereditary spastic paraplegia type SPG8. Orphanet J Rare Dis 10:147 (2015). PubMed: 26572744
  • Ramakrishnan R  et al. Oxidized lipids block antigen cross-presentation by dendritic cells in cancer. J Immunol 192:2920-31 (2014). ICC ; Mouse, Human . PubMed: 24554775
  • Olofsson A  et al. Uptake of Helicobacter pylori vesicles is facilitated by clathrin-dependent and clathrin-independent endocytic pathways. MBio 5:e00979-14 (2014). IF . PubMed: 24846379
  • Kozyreva VK  et al. NEDD9 regulates actin dynamics through cortactin deacetylation in an AURKA/HDAC6-dependent manner. Mol Cancer Res 12:681-93 (2014). PubMed: 24574519
  • Wu XA  et al. Intracellular fate of spherical nucleic acid nanoparticle conjugates. J Am Chem Soc 136:7726-33 (2014). PubMed: 24841494
  • Riley AM  et al. Cellular internalisation of an inositol phosphate visualised by using fluorescent InsP5. Chembiochem 15:57-67 (2014). PubMed: 24311195
  • Diner I  et al. Aggregation properties of the small nuclear ribonucleoprotein U1-70K in Alzheimer disease. J Biol Chem 289:35296-313 (2014). PubMed: 25355317
  • Li J  et al. SNX13 reduction mediates heart failure through degradative sorting of apoptosis repressor with caspase recruitment domain. Nat Commun 5:5177 (2014). PubMed: 25295779
  • Stack J  et al. TRAM is required for TLR2 endosomal signaling to type I IFN induction. J Immunol 193:6090-102 (2014). PubMed: 25385819
  • Allen SJ  et al. Binding of HSV-1 glycoprotein K (gK) to signal peptide peptidase (SPP) is required for virus infectivity. PLoS One 9:e85360 (2014). ICC/IF . PubMed: 24465545
  • Chen D  et al. Glioma cell proliferation controlled by ERK activity-dependent surface expression of PDGFRA. PLoS One 9:e87281 (2014). ICC/IF ; Human . PubMed: 24489888
  • Fathinajafabadi A  et al. CERKL, a retinal disease gene, encodes an mRNA-binding protein that localizes in compact and untranslated mRNPs associated with microtubules. PLoS One 9:e87898 (2014). ICC/IF ; Human . PubMed: 24498393
  • Müller J  et al. O-fucosylation of the notch ligand mDLL1 by POFUT1 is dispensable for ligand function. PLoS One 9:e88571 (2014). ICC/IF ; Mouse . PubMed: 24533113
  • Jin RU & Mills JC RAB26 coordinates lysosome traffic and mitochondrial localization. J Cell Sci 127:1018-32 (2014). PubMed: 24413166
  • Taha MS  et al. Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin. PLoS One 9:e91465 (2014). ICC/IF ; Human . PubMed: 24658146
  • Greer AM  et al. Serum IgE clearance is facilitated by human FceRI internalization. J Clin Invest 124:1187-98 (2014). ICC/IF . PubMed: 24569373
  • Vermehren-Schmaedick A  et al. Heterogeneous intracellular trafficking dynamics of brain-derived neurotrophic factor complexes in the neuronal soma revealed by single quantum dot tracking. PLoS One 9:e95113 (2014). IHC ; Rat . PubMed: 24732948
  • Yermakova A  et al. Antibody-mediated inhibition of ricin toxin retrograde transport. MBio 5:e00995 (2014). ICC/IF ; African green monkey . PubMed: 24713323
  • Srivastava L  et al. Immunomodulatory glycan lacto-N-fucopentaose III requires clathrin-mediated endocytosis to induce alternative activation of antigen-presenting cells. Infect Immun 82:1891-903 (2014). PubMed: 24566617
  • Kawasaki N  et al. Targeted delivery of mycobacterial antigens to human dendritic cells via Siglec-7 induces robust T cell activation. J Immunol 193:1560-6 (2014). PubMed: 25000981
  • Choi CH  et al. Mechanism for the endocytosis of spherical nucleic acid nanoparticle conjugates. Proc Natl Acad Sci U S A 110:7625-30 (2013). ICC/IF . PubMed: 23613589
  • Giudice J  et al. Insulin and insulin like growth factor II endocytosis and signaling via insulin receptor B. Cell Commun Signal 11:18 (2013). Human . PubMed: 23497114
  • Windhorst S  et al. Tumour cells can employ extracellular Ins(1,2,3,4,5,6)P(6) and multiple inositol-polyphosphate phosphatase 1 (MINPP1) dephosphorylation to improve their proliferation. Biochem J 450:115-25 (2013). PubMed: 23186306
  • Arany S  et al. Nanoparticle-mediated Gene Silencing Confers Radioprotection to Salivary Glands In Vivo. Mol Ther 21:1182-94 (2013). Mouse . PubMed: 23511246
  • Masuzawa A  et al. Transplantation of autologously derived mitochondria protects the heart from ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 304:H966-82 (2013). ICC/IF . PubMed: 23355340
  • Burg VK  et al. Plant sterols the better cholesterol in Alzheimer's disease? A mechanistical study. J Neurosci 33:16072-87 (2013). PubMed: 24107941
  • Caster AH & Kahn RA Recruitment of the Mint3 adaptor is necessary for export of the amyloid precursor protein (APP) from the Golgi complex. J Biol Chem 288:28567-80 (2013). ICC/IF ; Human . PubMed: 23965993
  • Wang H  et al. Enhanced endoplasmic reticulum entry of tumor antigen is crucial for cross-presentation induced by dendritic cell-targeted vaccination. J Immunol 191:6010-21 (2013). PubMed: 24218449
  • Nakayama A  et al. Ephrin-B2 controls PDGFRß internalization and signaling. Genes Dev 27:2576-89 (2013). ICC/IF ; Mouse . PubMed: 24298057
  • Khundadze M  et al. A hereditary spastic paraplegia mouse model supports a role of ZFYVE26/SPASTIZIN for the endolysosomal system. PLoS Genet 9:e1003988 (2013). Mouse . PubMed: 24367272
  • Kelly C  et al. Toll-like receptor 4 is not targeted to the lysosome in cystic fibrosis airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 304:L371-82 (2013). PubMed: 23316065
  • Perrot G  et al. LRP-1--CD44, a new cell surface complex regulating tumor cell adhesion. Mol Cell Biol 32:3293-307 (2012). PubMed: 22711991
  • Morén B  et al. EHD2 regulates caveolar dynamics via ATP-driven targeting and oligomerization. Mol Biol Cell 23:1316-29 (2012). PubMed: 22323287
  • Youn JI  et al. Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice. J Leukoc Biol 91:167-81 (2012). PubMed: 21954284
  • Abramowski D  et al. Transgenic expression of intraneuronal Aß42 but not Aß40 leads to cellular Aß lesions, degeneration, and functional impairment without typical Alzheimer's disease pathology. J Neurosci 32:1273-83 (2012). ICC/IF ; Mouse . PubMed: 22279212
  • Xu Y  et al. Epidermal Growth Factor-induced Vacuolar (H+)-ATPase Assembly: A ROLE IN SIGNALING VIA mTORC1 ACTIVATION. J Biol Chem 287:26409-22 (2012). ICC/IF . PubMed: 22689575
  • Cho KJ  et al. Staurosporines disrupt phosphatidylserine trafficking and mislocalize ras proteins. J Biol Chem 287:43573-84 (2012). PubMed: 23124205
  • Das S & Pellett PE Spatial Relationships between Markers for Secretory and Endosomal Machinery in Human Cytomegalovirus-Infected Cells versus Those in Uninfected Cells. J Virol 85:5864-79 (2011). PubMed: 21471245
  • Grimm MO  et al. Docosahexaenoic Acid Reduces Amyloid {beta} Production via Multiple Pleiotropic Mechanisms. J Biol Chem 286:14028-39 (2011). WB ; Human . PubMed: 21324907
  • Giudice J  et al. Differential endocytosis and signaling dynamics of insulin receptor variants IR-A and IR-B. J Cell Sci 124:801-11 (2011). PubMed: 21303927
  • Iyengar S  et al. Functional analysis of KAP1 genomic recruitment. Mol Cell Biol 31:1833-47 (2011). ICC/IF ; Human . PubMed: 21343339
  • Ha SD  et al. Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm. J Biol Chem 285:2120-9 (2010). WB ; Human . PubMed: 19858192
  • Joset A  et al. Pincher-generated Nogo-A endosomes mediate growth cone collapse and retrograde signaling. J Cell Biol 188:271-85 (2010). ICC/IF ; Rat . PubMed: 20083601
  • Sengers BG  et al. Characterisation of human bone marrow stromal cell heterogeneity for skeletal regeneration strategies using a two-stage colony assay and computational modelling. Bone 46:496-503 (2010). PubMed: 19818885
  • Lee PW  et al. The characteristics, biodistribution, magnetic resonance imaging and biodegradability of superparamagnetic core-shell nanoparticles. Biomaterials 31:1316-24 (2010). PubMed: 19959224
  • Wang L  et al. Metabolic profiling of hearts exposed to sevoflurane and propofol reveals distinct regulation of fatty acid and glucose oxidation: CD36 and pyruvate dehydrogenase as key regulators in anesthetic-induced fuel shift. Anesthesiology 113:541-51 (2010). PubMed: 20683255
  • Zwart W  et al. The invariant chain transports TNF family member CD70 to MHC class II compartments in dendritic cells. J Cell Sci 123:3817-27 (2010). PubMed: 20971706
  • Pawliczek T & Crump CM Herpes simplex virus type 1 production requires a functional ESCRT-III complex but is independent of TSG101 and ALIX expression. J Virol 83:11254-64 (2009). WB ; Human . PubMed: 19692479
  • Tsitoura E  et al. Infection with herpes simplex type 1-based amplicon vectors results in an IRF3/7-dependent, TLR-independent activation of the innate antiviral response in primary human fibroblasts. J Gen Virol 90:2209-20 (2009). PubMed: 19515829
  • Desko MM  et al. Effects of N-glycosylation on the activity and localization of GlcNAc-6-sulfotransferase 1. Glycobiology 19:1068-77 (2009). PubMed: 19571171
  • Demonbreun AR  et al. Myoferlin is required for insulin-like growth factor response and muscle growth. FASEB J : (2009). PubMed: 20008164
  • Jabbour M  et al. Discrete domains of MARCH1 mediate its localization, functional interactions, and posttranscriptional control of expression. J Immunol 183:6500-12 (2009). ICC/IF ; Mouse . PubMed: 19880452
  • García CC  et al. Characterization of Junín virus particles inactivated by a zinc finger-reactive compound. Virus Res 143:106-13 (2009). WB ; African green monkey . PubMed: 19463727
  • Langlois S  et al. Caveolin-1 and -2 interact with connexin43 and regulate gap junctional intercellular communication in keratinocytes. Mol Biol Cell 19:912-28 (2008). WB ; Rat . PubMed: 18162583
  • Yamakawa Y  et al. Identification and functional characterization of a bovine orthologue to DC-SIGN. J Leukoc Biol 83:1396-403 (2008). PubMed: 18319290
  • Overmeyer JH  et al. Active ras triggers death in glioblastoma cells through hyperstimulation of macropinocytosis. Mol Cancer Res 6:965-77 (2008). PubMed: 18567800
  • Stadler K  et al. Amiodarone alters late endosomes and inhibits SARS coronavirus infection at a post-endosomal level. Am J Respir Cell Mol Biol 39:142-9 (2008). PubMed: 18314540
  • Young JS  et al. Tubulobulbar Complexes Are Intercellular Podosome-Like Structures That Internalize Intact Intercellular Junctions During Epithelial Remodeling Events in the Rat Testis. Biol Reprod : (2008). ICC/IF ; Mouse . PubMed: 18799754
  • Bergami M  et al. Uptake and recycling of pro-BDNF for transmitter-induced secretion by cortical astrocytes. J Cell Biol 183:213-21 (2008). IHC-FoFr ; Rat . PubMed: 18852301
  • Han J  et al. Interaction of Mint3 with Furin regulates the localization of Furin in the trans-Golgi network. J Cell Sci 121:2217-23 (2008). WB, ICC/IF ; Human . PubMed: 18544638
  • Philips JA  et al. ESCRT factors restrict mycobacterial growth. Proc Natl Acad Sci U S A 105:3070-3075 (2008). WB ; Mouse . PubMed: 18287038
  • Laifenfeld D  et al. Rab5 mediates an amyloid precursor protein signaling pathway that leads to apoptosis. J Neurosci 27:7141-53 (2007). ICC/IF, WB ; Mouse . PubMed: 17611268
  • Guo D  et al. Protein kinase C-epsilon coimmunoprecipitates with cytochrome oxidase subunit IV and is associated with improved cytochrome-c oxidase activity and cardioprotection. Am J Physiol Heart Circ Physiol 293:H2219-30 (2007). PubMed: 17660387
  • Winter D  et al. Down-modulation of CXCR3 surface expression and function in CD8+ T cells from cutaneous T cell lymphoma patients. J Immunol 179:4272-82 (2007). ICC/IF ; Human . PubMed: 17785868
  • Brough D & Rothwell NJ Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death. J Cell Sci 120:772-81 (2007). PubMed: 17284521
  • Bonaccorsi L  et al. Altered endocytosis of epidermal growth factor receptor in androgen receptor positive prostate cancer cell lines. J Mol Endocrinol 38:51-66 (2007). PubMed: 17242169
  • Lu C  et al. The PY motif of ENaC, mutated in Liddle syndrome, regulates channel internalization, sorting and mobilization from subapical pool. Traffic 8:1246-64 (2007). PubMed: 17605762
  • Pak Y  et al. Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination. J Cell Biol 175:631-45 (2006). PubMed: 17116753
  • Dal Molin F  et al. Cell entry and cAMP imaging of anthrax edema toxin. EMBO J 25:5405-13 (2006). PubMed: 17082768
  • Vagin O  et al. The role of the beta1 subunit of the Na,K-ATPase and its glycosylation in cell-cell adhesion. J Biol Chem 281:39573-87 (2006). PubMed: 17052981
  • Kalabis J  et al. Vangl1 protein acts as a downstream effector of intestinal trefoil factor (ITF)/TFF3 signaling and regulates wound healing of intestinal epithelium. J Biol Chem 281:6434-41 (2006). PubMed: 16410243
  • Mintern JD  et al. Viral interference with B7-1 costimulation: a new role for murine cytomegalovirus fc receptor-1. J Immunol 177:8422-31 (2006). ICC/IF ; Chinese hamster . PubMed: 17142739
  • Flasza M  et al. Regulation of the nuclear localization of the human Nedd4-related WWP1 protein by Notch. Mol Membr Biol 23:269-76 (2006). PubMed: 16785210
  • Stenmark H  et al. Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger. J Biol Chem 271:24048-54 (1996). PubMed: 8798641
  • Mu FT  et al. EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine "fingers" and contains a calmodulin-binding IQ motif. J Biol Chem 270:13503-11 (1995). PubMed: 7768953
  • Mant A  et al. Acid sensitive background potassium channels K2P3.1 and K2P9.1 undergo rapid dynamin-dependent endocytosis. Channels (Austin) 7:288-302 (0). PubMed: 23807092

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