Overview

  • Product nameAnti-EFCAB4B antibody
    See all EFCAB4B primary antibodies
  • Description
    Rabbit polyclonal to EFCAB4B
  • SpecificityEFCAB4B antibody is predicted to not cross-react with other EFCAB4 family members.
  • Tested applicationsSuitable for: ICC/IF, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    14 amino acid peptide near the carboxy terminus of Human EFCAB4B (GenBank NP_116069).

  • Positive control
    • Mouse Kidney Tissue Lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab105418 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 46 kDa.
IHC-P Use at an assay dependent concentration.

Target

  • FunctionCa(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
  • Sequence similaritiesBelongs to the EFCAB4 family.
    Contains 2 EF-hand domains.
  • Cellular localizationCytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • Calcium release-activated calcium channel regulator 2A antibody
    • CRAC channel regulator 2A antibody
    • CRACR2A antibody
    • EF hand calcium binding domain 4B antibody
    • EF hand calcium binding domain containing protein 4B antibody
    • EF-hand calcium-binding domain-containing protein 4B antibody
    • EFC4B_HUMAN antibody
    • EFCAB 4B antibody
    • Efcab4b antibody
    • FLJ33805 antibody
    • MGC4266 antibody
    see all

Anti-EFCAB4B antibody images

  • Immunofluorescence of EFCAB4B in Human kidney tissue with ab105418 at 20 ug/mL.
  • Immunohistochemistry of EFCAB4B in Human kidney tissue with ab105418 at 10 μg/mL.

  • Anti-EFCAB4B antibody (ab105418) at 1 µg/ml + Mouse kidney tissue lysate at 15 µg

    Predicted band size : 46 kDa

References for Anti-EFCAB4B antibody (ab105418)

ab105418 has not yet been referenced specifically in any publications.

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