Overview

  • Product nameAnti-EFEMP1 antibody
    See all EFEMP1 primary antibodies
  • Description
    Rabbit polyclonal to EFEMP1
  • SpecificityThis antibody detects a strong 62 kDa EFEMP1 protein in human RPE cell extracts. The antibody does not cross-react with any other protein in RPE cells.
  • Tested applicationsSuitable for: WB, IPmore details
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Synthetic peptide:

    TYTQCTDGYEWDPVRQQC

    , corresponding to N terminal amino acids 25-42 of Human EFEMP1.

  • Positive control
    • Human RPE cell extracts.
  • General notes

    Storage of very dilute antibody solutions is not recommended, unless they are prepared in specially formulated multi use antibody dilution buffer. Positive control available as ab169709.

Properties

Applications

Our Abpromise guarantee covers the use of ab14926 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500. Detects a band of approximately 62 kDa (predicted molecular weight: 60 kDa).
IP 1/200.

Target

  • FunctionBinds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.
  • Tissue specificityIn the eye, associated with photoreceptor outer and inner segment regions, the nerve fiber layer, outer nuclear layer and inner and outer plexiform layers of the retina.
  • Involvement in diseaseDefects in EFEMP1 are a cause of Doyne honeycomb retinal dystrophy (DHRD) [MIM:126600]; also known as malattia leventinese (MLVT) (ML). DHRD is an autosomal dominant disease characterized by yellow-white deposits known as drusen that accumulate beneath the retinal pigment epithelium.
  • Sequence similaritiesBelongs to the fibulin family.
    Contains 6 EGF-like domains.
  • Cellular localizationSecreted > extracellular space. Secreted > extracellular space > extracellular matrix. Localizes to the lamina propria underneath the olfactory epithelium.
  • Information by UniProt
  • Database links
  • Alternative names
    • DHRD antibody
    • Doyne honeycomb retinal degeneration antibody
    • DRAD antibody
    • EFEMP 1 antibody
    • EFEMP1 antibody
    • EGF containing fibulin like extracellular matrix protein 1 antibody
    • EGF containing fibulin like extracellular matrix protein 1 precursor antibody
    • EGF-containing fibulin-like extracellular matrix protein 1 antibody
    • Epidermal growth factor containing fibulin like extracellular matrix protein 1 antibody
    • Extracellular protein S1 5 antibody
    • Extracellular protein S1-5 antibody
    • FBLN 3 antibody
    • FBLN3 antibody
    • FBLN3_HUMAN antibody
    • FBNL antibody
    • FIBL 3 antibody
    • FIBL-3 antibody
    • FIBL3 antibody
    • Fibrillin like antibody
    • Fibrillin like protein antibody
    • Fibrillin-like protein antibody
    • FIBULIN 3 antibody
    • Fibulin-3 antibody
    • Fibulin3 antibody
    • FLJ35535 antibody
    • Heat shock 70 KD protein 1 antibody
    • MGC111353 antibody
    • MLVT antibody
    • MTLV antibody
    • S1 5 antibody
    • T16 protein antibody
    see all

References for Anti-EFEMP1 antibody (ab14926)

This product has been referenced in:
  • Yang T  et al. Epigenetic inactivation of EFEMP1 is associated with tumor suppressive function in endometrial carcinoma. PLoS One 8:e67458 (2013). WB, IHC ; Human . Read more (PubMed: 23840707) »
  • Camaj P  et al. EFEMP1 binds the EGF receptor and activates MAPK and Akt pathways in pancreatic carcinoma cells. Biol Chem 390:1293-302 (2009). WB . Read more (PubMed: 19804359) »

See all 2 Publications for this product

Product Wall

This antibody is in an antibody stabilization buffer. This buffer mainly contains:

- Tris/glycine buffer pH 7.4-7.8
- Cryo-protective agents
- Stabilizing proteins (BSA)
- Glycerol

0.02% sodium azide is also present...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"