Overview

  • Product nameAnti-EFEMP1 antibody
    See all EFEMP1 primary antibodies
  • Description
    Rabbit polyclonal to EFEMP1
  • Tested applicationsSuitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 395-444 (KYMSIRSDRSVPSDIFQIQATTIYANTINTFRIKSGNENGEFYLRQTSP V) of Human EFEMP1 (NP_004096).

  • Positive control
    • 721_B cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab83087 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 53 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ICC/IF Use at an assay dependent concentration. PubMed: 22665518

Target

  • FunctionBinds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.
  • Tissue specificityIn the eye, associated with photoreceptor outer and inner segment regions, the nerve fiber layer, outer nuclear layer and inner and outer plexiform layers of the retina.
  • Involvement in diseaseDefects in EFEMP1 are a cause of Doyne honeycomb retinal dystrophy (DHRD) [MIM:126600]; also known as malattia leventinese (MLVT) (ML). DHRD is an autosomal dominant disease characterized by yellow-white deposits known as drusen that accumulate beneath the retinal pigment epithelium.
  • Sequence similaritiesBelongs to the fibulin family.
    Contains 6 EGF-like domains.
  • Cellular localizationSecreted > extracellular space. Secreted > extracellular space > extracellular matrix. Localizes to the lamina propria underneath the olfactory epithelium.
  • Information by UniProt
  • Database links
  • Alternative names
    • DHRD antibody
    • Doyne honeycomb retinal degeneration antibody
    • DRAD antibody
    • EFEMP 1 antibody
    • EFEMP1 antibody
    • EGF containing fibulin like extracellular matrix protein 1 antibody
    • EGF containing fibulin like extracellular matrix protein 1 precursor antibody
    • EGF-containing fibulin-like extracellular matrix protein 1 antibody
    • Epidermal growth factor containing fibulin like extracellular matrix protein 1 antibody
    • Extracellular protein S1 5 antibody
    • Extracellular protein S1-5 antibody
    • FBLN 3 antibody
    • FBLN3 antibody
    • FBLN3_HUMAN antibody
    • FBNL antibody
    • FIBL 3 antibody
    • FIBL-3 antibody
    • FIBL3 antibody
    • Fibrillin like antibody
    • Fibrillin like protein antibody
    • Fibrillin-like protein antibody
    • FIBULIN 3 antibody
    • Fibulin-3 antibody
    • Fibulin3 antibody
    • FLJ35535 antibody
    • Heat shock 70 KD protein 1 antibody
    • MGC111353 antibody
    • MLVT antibody
    • MTLV antibody
    • S1 5 antibody
    • T16 protein antibody
    see all

Anti-EFEMP1 antibody images

References for Anti-EFEMP1 antibody (ab83087)

This product has been referenced in:
  • Lutter S  et al. Smooth muscle-endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation. J Cell Biol 197:837-49 (2012). WB, ICC/IF ; Mouse . Read more (PubMed: 22665518) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"