Overview

  • Product nameAnti-EFHC1 antibody
    See all EFHC1 primary antibodies
  • Description
    Rabbit polyclonal to EFHC1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Full length protein, corresponding to amino acids 1-640 of Human EFHC1 (AAH20210.1).

  • Positive control
    • Mouse testis; EFHC1 transfected 293T cell line lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab103824 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 74 kDa.

Target

  • FunctionNecessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration (PubMed:22926142). May enhance calcium influx through CACNA1E and stimulate programmed cell death (PubMed:15258581).
  • Tissue specificityWidely expressed. Not detected in lymphocytes.
  • Involvement in diseaseJuvenile myoclonic epilepsy 1
    Juvenile absence epilepsy 1
    Mutation Leu-229 may be a cause of intractable epilepsy of infancy. Affected individuals have seizures of multiple type, manifested as tonic, clonic, and myoclonic seizures in the neonatal period, and as tonic seizures activated frequently by sleep, and repeated frequent myoclonic seizures in later infancy. The seizures are unresponsive to numerous antiepileptic drugs, and infants die in the first years of life. Although heterozygosity for Leu-229 has been associated with relatively benign forms of epilepsy in adolescence, homozygosity for the same mutation has much more severe consequences.
  • Sequence similaritiesContains 3 DM10 domains.
    Contains 1 EF-hand domain.
  • Cellular localizationCytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle.
  • Information by UniProt
  • Database links
  • Alternative names
    • EF hand domain (C terminal) containing 1 antibody
    • EF hand domain containing protein 1 antibody
    • EF-hand domain-containing protein 1 antibody
    • Efhc1 antibody
    • EFHC1_HUMAN antibody
    • EJA1 antibody
    • EJM1 antibody
    • FLJ10466 antibody
    • FLJ37290 antibody
    • JAE antibody
    • Myoclonin 1 antibody
    • Myoclonin-1 antibody
    see all

Anti-EFHC1 antibody images

  • Anti-EFHC1 antibody (ab103824) at 5 µg/ml + Mouse testis tissue lysate at 50 µg

    Predicted band size : 74 kDa
  • All lanes : Anti-EFHC1 antibody (ab103824) at 5 µg/ml

    Lane 1 : EFHC1 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 74 kDa

References for Anti-EFHC1 antibody (ab103824)

ab103824 has not yet been referenced specifically in any publications.

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