The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 27 kDa.
Use a concentration of 5 µg/ml.
FunctionMay regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis (By similarity). Plays a role as negative regulator of the canonical NF-kappa-B-activating branch (By similarity). Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.
Tissue specificityFound in lymphocytes; preferentially expressed in CD8+ cells.
Sequence similaritiesContains 2 EF-hand domains.
Cellular localizationMembrane raft. In immature B-cell line WEHI231.