Anti-EFHD2/SWS1 antibody (ab24368)
Key features and details
- Goat polyclonal to EFHD2/SWS1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-EFHD2/SWS1 antibody
See all EFHD2/SWS1 primary antibodies -
Description
Goat polyclonal to EFHD2/SWS1 -
Host species
Goat -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Cow, Dog -
Immunogen
Synthetic peptide corresponding to Human EFHD2/SWS1 aa 230-240 (C terminal).
Sequence:(C)AAFKELQSTFK
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Positive control
- WB: Human thymus, lymph node and tonsil lysates.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab24368 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use a concentration of 0.5 - 1.5 µg/ml. Detects a band of approximately 28-30 kDa.
1 hour primary incubation is recommended for this product. |
Notes |
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WB
Use a concentration of 0.5 - 1.5 µg/ml. Detects a band of approximately 28-30 kDa. 1 hour primary incubation is recommended for this product. |
Target
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Function
May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis (By similarity). Plays a role as negative regulator of the canonical NF-kappa-B-activating branch (By similarity). Controls spontaneous apoptosis through the regulation of BCL2L1 abundance. -
Tissue specificity
Found in lymphocytes; preferentially expressed in CD8+ cells. -
Sequence similarities
Contains 2 EF-hand domains. -
Cellular localization
Membrane raft. In immature B-cell line WEHI231. - Information by UniProt
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Database links
- Entrez Gene: 79180 Human
- Entrez Gene: 27984 Mouse
- Entrez Gene: 298609 Rat
- SwissProt: Q96C19 Human
- SwissProt: Q9D8Y0 Mouse
- SwissProt: Q4FZY0 Rat
- Unigene: 465374 Human
- Unigene: 395598 Mouse
see all -
Alternative names
- EF hand domain containing protein 2 antibody
- EF hand domain family, member D2 antibody
- EF-hand domain-containing protein D2 antibody
see all
Images
Protocols
Datasheets and documents
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Datasheet download
References (4)
ab24368 has been referenced in 4 publications.
- Wei X et al. Anti-Apoptosis of Podocytes and Pro-Apoptosis of Mesangial Cells for Telmisartan in Alleviating Diabetic Kidney Injury. Front Pharmacol 13:876469 (2022). PubMed: 35517816
- Wang Y et al. Schisandrin C attenuates renal damage in diabetic nephropathy by regulating macrophage polarization. Am J Transl Res 13:210-222 (2021). PubMed: 33527019
- Zhang S et al. Swiprosin-1 deficiency impairs macrophage immune response of septic mice. JCI Insight 3:N/A (2018). PubMed: 29415882
- Borger E et al. The calcium-binding protein EFhd2 modulates synapse formation in vitro and is linked to human dementia. J Neuropathol Exp Neurol 73:1166-82 (2014). WB . PubMed: 25383639