Overview

  • Product nameAnti-EFTUD2 antibody
    See all EFTUD2 primary antibodies
  • Description
    Rabbit polyclonal to EFTUD2
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Dog, Turkey, Pig, Xenopus laevis, Caenorhabditis elegans, Chimpanzee, Zebrafish, Rhesus monkey, Gorilla, Orangutan, Xenopus tropicalis
  • Immunogen

    Synthetic peptide corresponding to a region between residues 1 and 50 of human EFTUD2 (NP_004238.2).

  • Positive control
    • Human laryngeal squamous cell carcinoma; mouse squamous cell carcinoma.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesab84501 was affinity purified using an epitope specific to EFTUD2 immobilized on solid support.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab84501 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notesIHC-P: 1/100 - 1/500.
    Epitope exposure is recommended.
    Epitope exposure with citrate buffer will enhance staining.

    Likely to work with frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionComponent of the U5 snRNP complex required for pre-mRNA splicing. Binds GTP.
    • Involvement in diseaseDefects in EFTUD2 are the cause of mandibulofacial dysostosis with microcephaly (MFDM) [MIM:610536]. A rare syndrome characterized by progressive microcephaly, midface and malar hypoplasia, micrognathia, microtia, dysplastic ears, preauricular skin tags, significant developmental delay, and speech delay. Many patients have major sequelae, including choanal atresia that results in respiratory difficulties, conductive hearing loss, and cleft palate.
    • Sequence similaritiesBelongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
    • Post-translational
      modifications
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • 116 kDa antibody
      • 116 kDa U5 small nuclear ribonucleoprotein component antibody
      • EFTUD2 antibody
      • Elongation factor Tu GTP binding domain containing 2 antibody
      • Elongation factor Tu GTP-binding domain-containing protein 2 antibody
      • hSNU114 antibody
      • MFDGA antibody
      • MFDM antibody
      • SNRNP116 antibody
      • Snrp116 antibody
      • Snu114 antibody
      • SNU114 homolog antibody
      • U5 116KD antibody
      • U5 small nuclear ribonucleoprotein component antibody
      • U5 snRNP specific protein, 116 kD antibody
      • U5 snRNP specific protein, 116 kDa antibody
      • U5 snRNP-specific protein antibody
      • U5-116 kDa antibody
      • U5-116KD antibody
      • U5S1_HUMAN antibody
      see all

    Anti-EFTUD2 antibody images

    • Staining of EFTUD2 by Immunohistochemistry on a formalin fixed, paraffin embedded section of human laryngeal squamous cell carcinoma using a 1/100 dilution of ab84501.
      Detection: DAB staining.
    • Staining of EFTUD2 by Immunohistochemistry on a formalin fixed, paraffin embedded section of mouse squamous cell carcinoma using a 1/100 dilution of ab84501.
      Detection: DAB staining.

    References for Anti-EFTUD2 antibody (ab84501)

    ab84501 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab84501.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"