Plays a role in membrane reorganization in response to nucleotide hydrolysis. Binds to liposomes and deforms them into tubules. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for normal fusion of myoblasts to skeletal muscle myotubes. Binds ATP; does not bind GTP.
Highly expressed in heart and moderately expressed in placenta, lung, and skeletal muscle.
Contains 1 EF-hand domain. Contains 1 EH domain.
The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins.
Cell membrane. Endosome membrane. Colocalizes with GLUT4 in intracellular tubulovesicular structures that are associated with cortical F-actin.