Overview

  • Product nameAnti-EI24 antibody
    See all EI24 primary antibodies
  • Description
    Rabbit polyclonal to EI24
  • SpecificityAt least two isoforms of EI24 are known to exist; ab117463 will only detect the larger isoform.
  • Tested applicationsSuitable for: ICC, WBmore details
  • Species reactivity
    Reacts with: Rat
    Predicted to work with: Mouse, Human
  • Immunogen

    Synthetic peptide corresponding to 19 amino acids near the C terminal of Human EI24 (NP_004870).

  • Positive control
    • Rat liver tissue lysate.
  • General notesAvoid repeated freeze thaw cycles and exposure to prolonged high temperatures.

Properties

Applications

Our Abpromise guarantee covers the use of ab117463 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC Use a concentration of 5 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 39 kDa.

Target

  • FunctionActs as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy.
  • Involvement in diseaseNote=EI24 is on a chromosomal region frequently deleted in solid tumors, and it is thought to play a role in breast and cervical cancer. Particularly, expression analysis of EI24 in cancerous tissues shows that EI24 loss is associated with tumor invasiveness.
  • Sequence similaritiesBelongs to the EI24 family.
  • Cellular localizationNucleus membrane. Cytoplasm. Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Ectopic P granules autophagy protein 4 homolog antibody
    • Ei24 antibody
    • EI24_HUMAN antibody
    • EPG4 antibody
    • Etoposide induced 2.4 mRNA antibody
    • Etoposide-induced protein 2.4 homolog antibody
    • p53-induced gene 8 protein antibody
    • PIG8 antibody
    • TP53I8 antibody
    • Tumor protein p53 inducible protein 8 antibody
    see all

Anti-EI24 antibody images

  • Lane 1 : Anti-EI24 antibody (ab117463) at 1 µg/ml
    Lane 2 : Anti-EI24 antibody (ab117463) at 2 µg/ml

    Lane 1 : Rat liver tissue lysate
    Lane 2 : Rat liver tissue lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 39 kDa
  • Immunohistochemistry of EI24 in rat liver tissue with ab117463 at 5 ug/mL.

References for Anti-EI24 antibody (ab117463)

ab117463 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"