Anti-eIF2B3 antibody - Carboxyterminal end (ab71248)


  • Product nameAnti-eIF2B3 antibody - Carboxyterminal end
    See all eIF2B3 primary antibodies
  • Description
    Rabbit polyclonal to eIF2B3 - Carboxyterminal end
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human eIF2B3 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH).

  • Positive control
    • A375 cell line lysate.


  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • PurityAmmonium Sulphate Precipitation
  • Purification notesThis antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas


Our Abpromise guarantee covers the use of ab71248 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Detects a band of approximately 27 kDa (predicted molecular weight: 32 kDa).
ELISA 1/1000.


  • FunctionCatalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
  • Involvement in diseaseDefects in EIF2B3 are a cause of leukodystrophy with vanishing white matter (VWM) [MIM:603896]. VWM is a leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy.
  • Sequence similaritiesBelongs to the eIF-2B gamma/epsilon subunits family.
  • Information by UniProt
  • Database links
  • FormIt localizes to the cytosol.
  • Alternative names
    • EI2BG_HUMAN antibody
    • EIF 2B antibody
    • eIF 2B GDP GTP exchange factor subunit gamma antibody
    • eIF-2B GDP-GTP exchange factor subunit gamma antibody
    • eIF2B-gamma antibody
    • Eif2b3 antibody
    • EIF2Bgamma antibody
    • Eukaryotic translation initiation factor 2B subunit 3 gamma antibody
    • Eukaryotic translation initiation factor 2B, gamma antibody
    • eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa antibody
    • OTTHUMP00000010262 antibody
    • OTTHUMP00000010263 antibody
    • Translation initiation factor eIF-2B subunit gamma antibody
    see all

Anti-eIF2B3 antibody - Carboxyterminal end images

  • Anti-eIF2B3 antibody - Carboxyterminal end (ab71248) at 1/100 dilution + A375 cell line lysate at 12.5 µg

    Predicted band size : 32 kDa
    Observed band size : 27 kDa (why is the actual band size different from the predicted?)

References for Anti-eIF2B3 antibody - Carboxyterminal end (ab71248)

ab71248 has not yet been referenced specifically in any publications.

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