Anti-EIF2S1 (phospho S51) antibody [E90] (ab32157)

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ab32157 has been referenced in 51 publications.

  • Jennings MD  et al. Fail-safe control of translation initiation by dissociation of eIF2a phosphorylated ternary complexes. Elife 6:N/A (2017). WB . PubMed: 28315520
  • Perego J  et al. Guanabenz Prevents d-Galactosamine/Lipopolysaccharide-Induced Liver Damage and Mortality. Front Immunol 8:679 (2017). WB ; Mouse . PubMed: 28659918
  • Mitchell JK  et al. Hepatitis C Virus Indirectly Disrupts DNA Damage-Induced p53 Responses by Activating Protein Kinase R. MBio 8:N/A (2017). PubMed: 28442604
  • Shelkovnikova TA  et al. Chronically stressed or stress-preconditioned neurons fail to maintain stress granule assembly. Cell Death Dis 8:e2788 (2017). IHC-P ; Mouse . PubMed: 28492545
  • Yan L  et al. Icariside II Effectively Reduces Spatial Learning and Memory Impairments in Alzheimer's Disease Model Mice Targeting Beta-Amyloid Production. Front Pharmacol 8:106 (2017). PubMed: 28337142
  • Dimasi P  et al. Modulation of p-eIF2a cellular levels and stress granule assembly/disassembly by trehalose. Sci Rep 7:44088 (2017). PubMed: 28276506
  • Woo M  et al. Kimchi attenuates fatty streak formation in the aorta of low-density lipoprotein receptor knockout mice via inhibition of endoplasmic reticulum stress and apoptosis. Nutr Res Pract 11:445-451 (2017). PubMed: 29209454
  • Thiessen SE  et al. The Role of Autophagy in Critical Illness-induced Liver Damage. Sci Rep 7:14150 (2017). PubMed: 29074879
  • Dong Y  et al. Sulfur availability regulates plant growth via glucose-TOR signaling. Nat Commun 8:1174 (2017). PubMed: 29079776
  • Lev A  et al. Anti-pancreatic cancer activity of ONC212 involves the unfolded protein response (UPR) and is reduced by IGF1-R and GRP78/BIP. Oncotarget 8:81776-81793 (2017). PubMed: 29137221
  • Qi Y  et al. Loss of Drosophila i-AAA protease, dYME1L, causes abnormal mitochondria and apoptotic degeneration. Cell Death Differ 23:291-302 (2016). PubMed: 26160069
  • Park IA  et al. Endoplasmic reticulum stress induces secretion of high-mobility group proteins and is associated with tumor-infiltrating lymphocytes in triple-negative breast cancer. Oncotarget 7:59957-59964 (2016). IHC . PubMed: 27494867
  • Szaflarski W  et al. Vinca alkaloid drugs promote stress-induced translational repression and stress granule formation. Oncotarget 7:30307-22 (2016). PubMed: 27083003
  • Fusakio ME  et al. Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver. Mol Biol Cell 27:1536-51 (2016). WB . PubMed: 26960794
  • Cormerais Y  et al. Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth. Cancer Res 76:4481-92 (2016). WB ; Human . PubMed: 27302165
  • Seiferling D  et al. Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt. EMBO Rep 17:953-64 (2016). WB . PubMed: 27154400
  • Celardo I  et al. Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson's disease. Cell Death Dis 7:e2271 (2016). PubMed: 27336715
  • Backlund M  et al. Endoplasmic reticulum stress increases AT1R mRNA expression via TIA-1-dependent mechanism. Nucleic Acids Res 44:3095-104 (2016). WB ; Human . PubMed: 26681690
  • Xia X  et al. Arginine Supplementation Recovered the IFN-?-Mediated Decrease in Milk Protein and Fat Synthesis by Inhibiting the GCN2/eIF2a Pathway, Which Induces Autophagy in Primary Bovine Mammary Epithelial Cells. Mol Cells 39:410-7 (2016). WB . PubMed: 27025389
  • Kline CL  et al. ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2a kinases. Sci Signal 9:ra18 (2016). WB . PubMed: 26884600
  • Averous J  et al. GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism. Sci Rep 6:27698 (2016). PubMed: 27297692
  • Lee YH  et al. Association between betatrophin/ANGPTL8 and non-alcoholic fatty liver disease: animal and human studies. Sci Rep 6:24013 (2016). WB . PubMed: 27045862
  • Tseng YY  et al. Functional analysis of the short isoform of orf virus protein OV20.0. J Virol 89:4966-79 (2015). PubMed: 25694596
  • Portovedo M  et al. Saturated fatty acids modulate autophagy's proteins in the hypothalamus. PLoS One 10:e0119850 (2015). PubMed: 25786112
  • Way SW  et al. Pharmaceutical integrated stress response enhancement protects oligodendrocytes and provides a potential multiple sclerosis therapeutic. Nat Commun 6:6532 (2015). WB . PubMed: 25766071
  • Ghosh S & Geahlen RL Stress Granules Modulate SYK to Cause Microglial Cell Dysfunction in Alzheimer's Disease. EBioMedicine 2:1785-98 (2015). PubMed: 26870803
  • Young SK  et al. Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response. J Biol Chem 290:28257-71 (2015). PubMed: 26446796
  • Wengrod J  et al. Phosphorylation of eIF2a triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma. Sci Signal 8:ra27 (2015). WB ; Human . PubMed: 25759478
  • Carrara M  et al. Crystal structures reveal transient PERK luminal domain tetramerization in endoplasmic reticulum stress signaling. EMBO J 34:1589-600 (2015). Mouse . PubMed: 25925385
  • Zucal C  et al. EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition. BMC Cancer 15:855 (2015). WB ; Human . PubMed: 26542945
  • Vaughn LS  et al. Altered activation of protein kinase PKR and enhanced apoptosis in dystonia cells carrying a mutation in PKR activator protein PACT. J Biol Chem 290:22543-57 (2015). PubMed: 26231208
  • Hsu WL  et al. The untranslated regions of classic swine fever virus RNA trigger apoptosis. PLoS One 9:e88863 (2014). WB . PubMed: 24533157
  • Sadleir KR  et al. Genetic inhibition of phosphorylation of the translation initiation factor eIF2a does not block Aß-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease. PLoS One 9:e101643 (2014). WB ; Mouse . PubMed: 24992504
  • Kosakowska-Cholody T  et al. HKH40A downregulates GRP78/BiP expression in cancer cells. Cell Death Dis 5:e1240 (2014). Human . PubMed: 24853418
  • Nallagatla SR  et al. Native tertiary structure and nucleoside modifications suppress tRNA's intrinsic ability to activate the innate immune sensor PKR. PLoS One 8:e57905 (2013). WB . PubMed: 23483938
  • Banduseela VC  et al. Impaired autophagy, chaperone expression, and protein synthesis in response to critical illness interventions in porcine skeletal muscle. Physiol Genomics 45:477-86 (2013). PubMed: 23572537
  • B'chir W  et al. The eIF2a/ATF4 pathway is essential for stress-induced autophagy gene expression. Nucleic Acids Res 41:7683-99 (2013). WB ; Mouse . PubMed: 23804767
  • Yang PM  et al. Zebularine inhibits tumorigenesis and stemness of colorectal cancer via p53-dependent endoplasmic reticulum stress. Sci Rep 3:3219 (2013). WB ; Human . PubMed: 24225777
  • Coope A  et al. Chaperone insufficiency links TLR4 protein signaling to endoplasmic reticulum stress. J Biol Chem 287:15580-9 (2012). WB ; Mouse . PubMed: 22427667
  • Tardito S  et al. L-Asparaginase and inhibitors of glutamine synthetase disclose glutamine addiction of ß-catenin-mutated human hepatocellular carcinoma cells. Curr Cancer Drug Targets 11:929-43 (2011). WB ; Human . PubMed: 21834755
  • Vanderperre B  et al. An overlapping reading frame in the PRNP gene encodes a novel polypeptide distinct from the prion protein. FASEB J 25:2373-86 (2011). PubMed: 21478263
  • Zhang F  et al. The African swine fever virus DP71L protein recruits the protein phosphatase 1 catalytic subunit to dephosphorylate eIF2alpha and inhibits CHOP induction but is dispensable for these activities during virus infection. J Virol 84:10681-9 (2010). PubMed: 20702639
  • Xu YX  et al. Inhibition of Golgi apparatus glycosylation causes endoplasmic reticulum stress and decreased protein synthesis. J Biol Chem 285:24600-8 (2010). PubMed: 20529871
  • Cantero-Recasens G  et al. The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress. Hum Mol Genet 19:111-21 (2010). WB ; Human . PubMed: 19819884
  • Gorbatyuk MS  et al. Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78. Proc Natl Acad Sci U S A 107:5961-6 (2010). WB ; Rat . PubMed: 20231467
  • Konsavage WM  et al. Hyperoxia Inhibits Protein Synthesis and Increases eIF2{alpha} Phosphorylation in the Newborn Rat Lung. Am J Physiol Lung Cell Mol Physiol : (2010). IHC-Fr ; Rat . PubMed: 20139179
  • Duffy C  et al. VP22 of herpes simplex virus 1 promotes protein synthesis at late times in infection and accumulation of a subset of viral mRNAs at early times in infection. J Virol 83:1009-17 (2009). WB ; African green monkey . PubMed: 18987147
  • Farny NG  et al. Metazoan stress granule assembly is mediated by P-eIF2alpha-dependent and -independent mechanisms. RNA 15:1814-21 (2009). WB ; Drosophila melanogaster . PubMed: 19661161
  • Parlati F  et al. Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome. Blood 114:3439-47 (2009). WB ; Human . PubMed: 19671918
  • Kren BT  et al. Polysome trafficking of transcripts and microRNAs in regenerating liver after partial hepatectomy. Am J Physiol Gastrointest Liver Physiol 297:G1181-92 (2009). PubMed: 19779017
  • Wu D  et al. 2-Aminopurine inhibits lipid accumulation induced by apolipoprotein E-deficient lipoprotein in macrophages: potential role of eukaryotic initiation factor-2alpha phosphorylation in foam cell formation. J Pharmacol Exp Ther 326:395-405 (2008). PubMed: 18463320


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