Overview

  • Product name
  • Description
    Chicken polyclonal to eIF3K
  • Specificity
    ab26937 recognises eukaryotic translation initiation factor 3 subunit 12(eIF3k, HSP27).
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human, Chimpanzee
    Predicted to work with: Mouse, Cow, Xenopus laevis, Zebrafish
  • Immunogen

    Fusion protein: LYQFNPAFFQ TTVTAQILLK ALTNLPHTDF TLCKCMIDQA HQ, corresponding to amino acids 53/94 of Human eIF3K

  • Positive control
    • Oral cancer epithelium

Properties

Applications

Our Abpromise guarantee covers the use of ab26937 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/500.
WB 1/3000. Predicted molecular weight: 25 kDa.

Target

  • Function
    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
  • Tissue specificity
    Ubiquitous, with the highest levels of expression in brain, testis and kidney.
  • Sequence similarities
    Belongs to the eIF-3 subunit K family.
  • Cellular localization
    Nucleus. Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • ARG134 antibody
    • eIF 3 p25 antibody
    • eIF 3 p28 antibody
    • eIF-3 p25 antibody
    • eIF-3 p28 antibody
    • EIF3-p28 antibody
    • eif3k antibody
    • EIF3K_HUMAN antibody
    • EIF3S12 antibody
    • Eukaryotic translation initiation factor 3 subunit 12 antibody
    • Eukaryotic translation initiation factor 3 subunit K antibody
    • HSPC029 antibody
    • M9 antibody
    • MSTP001 antibody
    • Muscle specific gene M9 protein antibody
    • Muscle-specific gene M9 protein antibody
    • PLAC 24 antibody
    • PLAC-24 antibody
    • PLAC24 antibody
    • PRO1474 antibody
    • PTD001 antibody
    see all

Images

  • Immunohistochemical analysis of eIF3K expression in (A) oral cancer epithelium using 1/500 ab26937. (B) represents staining of oral epithelium, as negative control.

References

ab26937 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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