Overview

  • Product nameAnti-eIF3s8 antibody
    See all eIF3s8 primary antibodies
  • Description
    Rabbit polyclonal to eIF3s8
  • Tested applicationsSuitable for: WB, IPmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
    Predicted to work with: Rabbit, Horse, Guinea pig, Cow, Dog, Chimpanzee, Gorilla, Chinese Hamster, Orangutan, Elephant
  • Immunogen

    Synthetic peptide corresponding to Human eIF3s8 aa 850-913 (C terminal).

  • Positive control
    • Whole cell lysate from HEK293 (human), C2C12 (mouse), and L6 (Rat) cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab19360 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/15000 - 1/30000. Detects a band of approximately 98 kDa (predicted molecular weight: 105 kDa).
IP Use at 2-10 µg/mg of lysate.

Target

  • FunctionComponent of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
  • Sequence similaritiesBelongs to the eIF-3 subunit C family.
    Contains 1 PCI domain.
  • Post-translational
    modifications
    Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
  • Cellular localizationCytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cell migration inducing protein 17 antibody
    • eIF 3c antibody
    • eIF3 p110 antibody
    • eIF3-p110 antibody
    • eIF3c antibody
    • EIF3C_HUMAN antibody
    • EIF3CL antibody
    • EIF3S8 antibody
    • EIF3S8 protein antibody
    • Eukaryotic translation initiation factor 3 subunit 8 (110kD) antibody
    • Eukaryotic translation initiation factor 3 subunit 8 110kDa antibody
    • Eukaryotic translation initiation factor 3 subunit 8 antibody
    • Eukaryotic translation initiation factor 3 subunit C antibody
    see all

Anti-eIF3s8 antibody images



  • Predicted band size : 105 kDa


    ab19360 at 0.04µg/ml for Western Blot (A and B) and at 5µg/mg for immunoprecipitation (B), staining (5, 15 or 50µg for Western blot) human HEK293, mouse C2C12 and rat L6 cells (A) and (1mg for immunoprecipitation) whole cell lysate from HEK293 cells (B). Detection was by chemiluminescence with exposure times of two to four minutes.

References for Anti-eIF3s8 antibody (ab19360)

ab19360 has not yet been referenced specifically in any publications.

Product Wall

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"