Overview

  • Product nameAnti-eIF4EBP1 antibody
    See all eIF4EBP1 primary antibodies
  • Description
    Rabbit polyclonal to eIF4EBP1
  • Tested applicationsSuitable for: ICC/IF, WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    14 amino acid synthetic peptide from near the C terminus of eIF4EBP1 (Human).

  • Positive control
    • 3T3 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab25872 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 2 µg/ml.
WB Use a concentration of 2.5 - 5 µg/ml. Detects a band of approximately 20 kDa (predicted molecular weight: 13 kDa).

Target

  • FunctionRegulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
  • Sequence similaritiesBelongs to the eIF4E-binding protein family.
  • Post-translational
    modifications
    Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-37, Thr-46, Ser-65 and Thr-70 is regulated by mTORC1. Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Information by UniProt
  • Database links
  • Alternative names
    • 4E-BP1 antibody
    • 4EBP1 antibody
    • 4EBP1_HUMAN antibody
    • BP 1 antibody
    • eIF4E binding protein 1 antibody
    • eIF4E-binding protein 1 antibody
    • Eif4ebp1 antibody
    • Eukaryotic translation initiation factor 4E-binding protein 1 antibody
    • PHAS-I antibody
    • PHASI antibody
    • Phosphorylated heat- and acid-stable protein regulated by insulin 1 antibody
    see all

Anti-eIF4EBP1 antibody images

  • Lane 1 : Anti-eIF4EBP1 antibody (ab25872) at 2.5 µg/ml
    Lane 2 : Anti-eIF4EBP1 antibody (ab25872) at 5 µg/ml
    Lane 3 : Anti-eIF4EBP1 antibody (ab25872) at 10 µg/ml

    Lane 1 : Human brain cell lysate
    Lane 2 : Human brain cell lysate
    Lane 3 : Human brain cell lysate


    Predicted band size : 13 kDa
  • ab25872 at 2µg/ml staining elf4EBP1 in 3T3 cells by ICC/IF

References for Anti-eIF4EBP1 antibody (ab25872)

ab25872 has not yet been referenced specifically in any publications.

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