Overview

  • Product nameAnti-eIF4G1 antibody
    See all eIF4G1 primary antibodies
  • Description
    Mouse monoclonal to eIF4G1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: DVAVLKARAK LLQKYLCDEQ KELQALYALQ ALVVTLEQPP NLLRMFFDAL YDEDVVKEDA FYSWESSKDP AEQQGKGVAL KSVTAFFKWL REAEEESDHN , corresponding to amino acids 1500-1600 of Human eIF4G1

Properties

Applications

Our Abpromise guarantee covers the use of ab54970 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionComponent of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.
    • Involvement in diseaseDefects in EIF4G1 are the cause of Parkinson disease type 18 (PARK18) [MIM:614251]. An autosomal dominant, late-onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.
    • Sequence similaritiesBelongs to the eIF4G family.
      Contains 1 MI domain.
      Contains 1 MIF4G domain.
      Contains 1 W2 domain.
    • Post-translational
      modifications
      Phosphorylated at multiple sites in vivo. Phosphorylation at Ser-1185 by PRKCA induces binding to MKNK1.
      Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription.
    • Information by UniProt
    • Database links
    • Alternative names
      • DKFZp686A1451 antibody
      • eIF 4 gamma 1 antibody
      • eIF 4G 1 antibody
      • eIF 4G1 antibody
      • eIF-4-gamma 1 antibody
      • eIF-4G 1 antibody
      • eIF-4G1 antibody
      • EIF4 gamma antibody
      • EIF4F antibody
      • EIF4G antibody
      • EIF4G1 antibody
      • EIF4GI antibody
      • Eukaryotic translation initiation factor 4 gamma 1 antibody
      • IF4G1_HUMAN antibody
      • p220 antibody
      see all

    Anti-eIF4G1 antibody images



    • Predicted band size : 176 kDa
      eIF4G1 antibody (ab54970) at 1ug/lane + HepG2 cell lysate at 25ug/lane.

    References for Anti-eIF4G1 antibody (ab54970)

    This product has been referenced in:
    • Gumireddy K  et al. Identification of a long non-coding RNA-associated RNP complex regulating metastasis at the translational step. EMBO J 32:2672-84 (2013). Read more (PubMed: 23974796) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"