Overview

  • Product nameAnti-eIF4H antibody
    See all eIF4H primary antibodies
  • Description
    Rabbit polyclonal to eIF4H
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Chimpanzee, Rhesus monkey, Gorilla, Chinese Hamster, Orangutan
  • Immunogen

    Synthetic peptide, corresponding to a region within amino acids 198-248 of Human eIF4H (NP_071496.1).

  • Positive control
    • Human Colon Carcinoma, Prostate Carcinoma and Testicular Seminoma tissues

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab114850 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining

Target

  • FunctionStimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.
  • Tissue specificityThe short isoform is the predominant isoform and is expressed alone in liver and skeletal muscle. Both isoforms are expressed in fibroblast, spleen, testis and bone marrow. Levels are high in lung and pancreas and low in heart, frontal cortex and kidney.
  • Involvement in diseaseNote=EIF4H is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of EIF4H may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
  • Sequence similaritiesContains 1 RRM (RNA recognition motif) domain.
  • Cellular localizationCytoplasm > perinuclear region.
  • Information by UniProt
  • Database links
  • Alternative names
    • AU018978 antibody
    • D5Ertd355e antibody
    • E430026L18Rik antibody
    • Ef4h antibody
    • eIF 4H antibody
    • eIF-4H antibody
    • EIF4H antibody
    • Eukaryotic translation initiation factor 4H antibody
    • IF4H_HUMAN antibody
    • KIAA0038 antibody
    • WBSCR1 antibody
    • Williams Beuren syndrome chromosomal region 1 protein homolog antibody
    • Williams Beuren syndrome chromosome region 1 antibody
    • Williams-Beuren syndrome chromosomal region 1 protein antibody
    • Williams-Beuren syndrome chromosome region 1 antibody
    • WSCR1 antibody
    see all

Anti-eIF4H antibody images

  • ab114850, at 1/250 dilution, staining eIF4H in formalin-fixed, paraffin-embedded Human prostate carcinoma tissue by Immunohistochemistry with DAB staining.

References for Anti-eIF4H antibody (ab114850)

ab114850 has not yet been referenced specifically in any publications.

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