EKLF / KLF1 peptide (ab45462)

General Info

• Alternative names
  • CDAN4
  • EKLF
  • EKLF PEN

  • Erythroid krueppel like transcription factor (EKLF) (Erythroid transcription factor)
  • Erythroid krueppel-like transcription factor
  • Erythroid Kruppel like factor
  • Erythroid specific transcription factor EKLF
  • HBFQTL6
  • Human erythroid-specific transcription factor EKLF mRNA complete cds
  • INLU
  • Klf1
  • KLF1_HUMAN
  • Krueppel-like factor 1
  • Kruppel like factor 1 (erythroid)

  see all
• Function
  Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.
• Tissue specificity
  Expression restricted to adult bone marrow and fetal liver. Not expressed in myeloid nor lymphoid cell lines.
• Involvement in disease
  Defects in KLF1 are the cause of congenital dyserythropoietic anemia type 4 (CDA4) [MIM:613673]. It is a blood disorder characterized by ineffective erythropoiesis and hemolysis resulting in anemia. Circulating erythroblasts and erythroblasts in the bone marrow show various morphologic abnormalities. Affected individuals with CDA4 also have increased levels of fetal hemoglobin.
• Sequence similarities
  Belongs to the krueppel C2H2-type zinc-finger protein family.
  Contains 3 C2H2-type zinc fingers.
• Post-translational
  modifications
  Acetylated; can be acetylated on both Lys-274 and Lys-288. Acetylation on Lys-274 (by CBP) appears to be the major site affecting EKLF transactivation activity.
  Sumoylated; sumoylation, promoted by PIAS1, leads to repression of megakaryocyte differentiation. Also promotes the interaction with the CDH4 subunit of the NuRD repression complex.
  Phosphorylated primarily on serine residues in the transactivation domain. Phosphorylation on Thr-23 is critical for the transactivation activity.
• Cellular localization
  Nucleus. Colocalizes with SUMO1 in nuclear speckles.

• Target information above from: UniProt accession Q13351 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt