Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab2271 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 75 kDa (predicted molecular weight: 81 kDa).

Target

  • Function
    Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
  • Sequence similarities
    Contains 1 ELMO domain.
    Contains 1 PH domain.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • CED 12 antibody
    • Ced 12 homolog 3 antibody
    • CED12 antibody
    • ELMO 3 antibody
    • ELMO3 antibody
    • ELMO3_HUMAN antibody
    • Engulfment and cell motility 3 antibody
    • Engulfment and cell motility protein 3 antibody
    • FLJ13824 antibody
    see all

Images

References

This product has been referenced in:
  • Ikhapoh IA  et al. Atherogenic Cytokines Regulate VEGF-A-Induced Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells into Endothelial Cells. Stem Cells Int 2015:498328 (2015). IF . Read more (PubMed: 26106428) »

See 1 Publication for this product

Customer reviews and Q&As

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