Overview

  • Product name
    EMD 386088 hydrochloride
  • Description
    Potent 5-HT6 agonist
  • Biological description
    Potent 5-HT6 agonist (IC50 = 7.4 nM in 3H-LSD binding and EC50 = 1.0 nM in a functional cAMP assay). Selective over other 5-HT receptors (IC50 values are 110 (5-HT1D), 180 (5-HT1B), 240 (5-HT2A), 450 (5-HT2C), 620 (5-HT4), 660 (5-HT1A ) and 3000 nM (5-HT7)). Shows moderate affinity at 5-HT3 receptors (IC50 = 34 nM). Impairs memory in vivo.
  • Purity
    > 98%

Properties

References

This product has been referenced in:
  • Castañeda-Corral G  et al. Role of peripheral and spinal 5-HT6 receptors according to the rat formalin test. Neuroscience 162:444-52 (2009). Read more (PubMed: 19422883) »
  • Meneses A  et al. The effects of the 5-HT(6) receptor agonist EMD and the 5-HT(7) receptor agonist AS19 on memory formation. Behav Brain Res 195:112-9 (2008). Read more (PubMed: 18191236) »
  • Mattsson C  et al. 2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists. Bioorg Med Chem Lett 15:4230-4 (2005). Read more (PubMed: 16055331) »

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