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EMD 386088 hydrochloride
6 agonist (IC 50 = 7.4 nM in 3H-LSD binding and EC 50 = 1.0 nM in a functional cAMP assay). Selective over other 5-HT receptors (IC 50 values are 110 (5-HT 1D), 180 (5-HT 1B), 240 (5-HT 2A), 450 (5-HT 2C), 620 (5-HT 4), 660 (5-HT 1A ) and 3000 nM (5-HT 7)). Shows moderate affinity at 5-HT 3 receptors (IC 50 = 34 nM). Impairs memory in vivo.
14H 15N 2.HCl
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in water to 25 mM (with heating) and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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References for EMD 386088 hydrochloride (ab120328)
This product has been referenced in:
et al. Role of peripheral and spinal 5-HT6 receptors according to the rat formalin test. Neuroscience 162:444-52 (2009).
Read more (PubMed: 19422883) »
et al. The effects of the 5-HT(6) receptor agonist EMD and the 5-HT(7) receptor agonist AS19 on memory formation. Behav Brain Res 195:112-9 (2008).
Read more (PubMed: 18191236) »
et al. 2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists. Bioorg Med Chem Lett 15:4230-4 (2005).
Read more (PubMed: 16055331) »
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"