Anti-Emerin antibody [MANEM1(5D10)] (ab125932)


  • Product nameAnti-Emerin antibody [MANEM1(5D10)]
    See all Emerin primary antibodies
  • Description
    Mouse monoclonal [MANEM1(5D10)] to Emerin
  • Tested applicationsSuitable for: ICC/IF, WBmore details
  • Species reactivity
    Reacts with: Rabbit, Human
    Does not react with: Mouse
  • Immunogen

    Recombinant fragment of Emerin amino acids 1-188(Human)

  • Positive control
    • Human fibroblast cells and cell extracts.


  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: 0.1% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • Clone numberMANEM1(5D10)
  • MyelomaSp2/0
  • IsotypeIgG1
  • Research areas


Our Abpromise guarantee covers the use of ab125932 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/4 - 1/10.
WB 1/400 - 1/800. Predicted molecular weight: 29 kDa.


  • FunctionStabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C.
  • Tissue specificitySkeletal muscle, heart, colon, testis, ovary and pancreas.
  • Involvement in diseaseDefects in EMD are the cause of Emery-Dreifuss muscular dystrophy type 1 (EDMD1) [MIM:310300]. A degenerative myopathy characterized by weakness and atrophy of muscle without involvement of the nervous system, early contractures of the elbows Achilles tendons and spine, and cardiomyopathy associated with cardiac conduction defects.
  • Sequence similaritiesContains 1 LEM domain.
  • Post-translational
    Found in four different phosphorylated forms, three of which appear to be associated with the cell cycle.
  • Cellular localizationNucleus inner membrane. Nucleus outer membrane. Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non-farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • EDMD antibody
    • Emd antibody
    • EMD_HUMAN antibody
    • Emerin antibody
    • Emery Dreifuss muscular dystrophy antibody
    • STA antibody
    see all

Anti-Emerin antibody [MANEM1(5D10)] images

  • Anti-Emerin antibody [MANEM1(5D10)] (ab125932) at 1/400 dilution + Normal Human fibroblast extracts

    Predicted band size : 29 kDa
  • ab125932 at 1/4 dilution staining Emerin in Human fibroblasts by Immunofluorescence. DAPI counterstaining.

References for Anti-Emerin antibody [MANEM1(5D10)] (ab125932)

ab125932 has not yet been referenced specifically in any publications.

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