Overview

  • Product name
  • Description
    Rabbit polyclonal to EMG1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to internal sequence amino acids 111-140 of Human EMG1 (NP_006322.4)

  • Positive control
    • Hela cell line lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab107293 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 27 kDa.

Target

  • Function
    S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position (PubMed:20047967). Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes.
  • Involvement in disease
    Bowen-Conradi syndrome
  • Sequence similarities
    Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
  • Cellular localization
    Nucleus, nucleolus.
  • Information by UniProt
  • Database links
  • Alternative names
    • 18S rRNA (pseudouridine(1248)-N1)-methyltransferase antibody
    • 18S rRNA Psi1248 methyltransferase antibody
    • C2F antibody
    • C2f protein antibody
    • EMG 1 antibody
    • EMG1 antibody
    • EMG1 N1 specific pseudouridine methyltransferase antibody
    • EMG1 nucleolar protein homolog (S cerevisiae) antibody
    • EMG1 nucleolar protein homolog antibody
    • essential for mitotic growth 1 antibody
    • FLJ60792 antibody
    • Grcc2f antibody
    • NEP1 antibody
    • NEP1_HUMAN antibody
    • Nucleolar protein EMG1 homolog antibody
    • Protein C2f antibody
    • Ribosomal RNA small subunit methyltransferase Nep1 antibody
    • Ribosome biogenesis protein NEP1 antibody
    see all

Images

  • Anti-EMG1 antibody (ab107293) at 1/100 dilution + HeLa cell lysate at 35 µg

    Predicted band size : 27 kDa

References

ab107293 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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