Human Predicted to work with:
Mouse, Rat, Chicken, Cow, Dog
Recombinant fragment: HSPHPLFASQ QRDPSTFYPW LIHRYRYLGH RFQGNDTSPE SFLLHNAL A RKPKRIRTAF SPSQLLRLEH AFEKNHYVVG AERKQLAHSL SLTETQVKVW, corresponding to amino acids 103-201 of Human EMX2 with a proprietary tag (NP_004089).
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration.
Use a concentration of 5 µg/ml.
FunctionTranscription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.
Tissue specificityCerebral cortex.
Involvement in diseaseDefects in EMX2 are the cause of schizencephaly (SCHZC) [MIM:269160]. Schizencephaly is an extremely rare human congenital disorder characterized by a full-thickness cleft within the cerebral hemispheres. These clefts are lined with gray matter and most commonly involve the parasylvian regions. Large portions of the cerebral hemispheres may be absent and replaced by cerebro-spinal fluid.
Sequence similaritiesBelongs to the EMX homeobox family. Contains 1 homeobox DNA-binding domain.