ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.
Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.
Involvement in disease
Defects in EMX2 are the cause of schizencephaly (SCHZC) [MIM:269160]. Schizencephaly is an extremely rare human congenital disorder characterized by a full-thickness cleft within the cerebral hemispheres. These clefts are lined with gray matter and most commonly involve the parasylvian regions. Large portions of the cerebral hemispheres may be absent and replaced by cerebro-spinal fluid.
Belongs to the EMX homeobox family. Contains 1 homeobox DNA-binding domain.
Anti-EMX2 antibody (ab174897) at 1/100 dilution + HL60 cell lysate at 35 µg
Predicted band size: 28 kDa
Flow Cytometry - Anti-EMX2 antibody (ab174897)
Flow cytometric analysis of HL-60 cells (right histogram) labeling EMX2 with ab174897 at 1/10 dilution compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.