Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab10289 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr 1/300.

Target

  • RelevanceEndomorphin-1 (Tyr-Pro-Trp-Phe-NH2, EM-1) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH2, EM-2)are endogenous tetrapeptides derived from an unknown precursor and have the highest affinity and selectivity for the mu-opioid receptor (MOP-R) of all known mammalian opioids. They have been isolated from bovine and human brain, and have a potent antinociceptive activity (inhibition of pain perception) and are involved in a number of physiological processes, including food intake, vasomotricity, sexual behavior, as well as neuroendocrine and cardiorespiratory functions. Opioidmimetics and opioid peptides containing the amino acid sequence of the message domain of endomorphins, Tyr-Pro-Phe/Trp, could exhibit unique binding activity and lead to the development of new therapeutic drugs for controlling pain.
  • Database links
  • Alternative names
    • EM 2 antibody

Anti-Endomorphin 2 antibody images

  • ab10289, at a dilution of 1/300, staining Endomorphin 2 in rat dorsal horn by Immunohistochemistry (PFA perfusion fixed frozen sections).
  • END-2 staining of neurons from neonatal rat lumbar (L4/5) DRG

References for Anti-Endomorphin 2 antibody (ab10289)

This product has been referenced in:
  • Luo DS  et al. Connections between EM2- and SP-containing terminals and GABAergic neurons in the mouse spinal dorsal horn. Neurol Sci 35:1421-7 (2014). Read more (PubMed: 24718557) »
  • Dou XL  et al. Synaptic Connections between Endomorphin 2-Immunoreactive Terminals and µ-Opioid Receptor-Expressing Neurons in the Sacral Parasympathetic Nucleus of the Rat. PLoS One 8:e62028 (2013). IHC ; Rat . Read more (PubMed: 23671582) »

See all 2 Publications for this product

Product Wall

Thank you for your enquiry. Endomorphins are 4-amino-acid peptides with molecular weight ~ 480 Daltons. Peptides with such a small weight cannot be run by western blotting - there is no such a gel that would allow retain such small peptides. Secon...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"