Anti-Endostatin antibody [KT58] (ab114141)

Overview

  • Product nameAnti-Endostatin antibody [KT58]
    See all Endostatin primary antibodies
  • Description
    Mouse monoclonal [KT58] to Endostatin
  • Tested applicationsSuitable for: Sandwich ELISA, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant Endostatin.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab114141 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Sandwich ELISA Use a concentration of 5 µg/ml. Can be paired for Sandwich ELISA with Mouse monoclonal [KT60] to Endostatin (HRP) (ab106491). For coating plates.
ELISA Use a concentration of 1 µg/ml.

Target

  • FunctionCOLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.
    Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
  • Tissue specificityPresent in multiple organs with highest levels in liver, lung and kidney.
  • Involvement in diseaseDefects in COL18A1 are a cause of Knobloch syndrome (KNO) [MIM:267750]. KNO is an autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele.
  • Sequence similaritiesBelongs to the multiplexin collagen family.
    Contains 1 FZ (frizzled) domain.
    Contains 1 TSP N-terminal (TSPN) domain.
  • Post-translational
    modifications
    Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
  • Cellular localizationSecreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • Alpha 1 collagen type 18 (XVIII)(COL18A1) antibody
    • Alpha 1 type XVIII collagen antibody
    • Antiangiogenic agent antibody
    • COIA1_HUMAN antibody
    • COL15A1 antibody
    • Col18a1 antibody
    • Collagen alpha 1(XV) chain antibody
    • Collagen alpha 1(XVIII) chain antibody
    • Collagen alpha-1(XV) chain antibody
    • Collagen type XV proteoglycan antibody
    • Collagen type XVIII alpha 1 antibody
    • Collagen XV, alpha 1 polypeptide antibody
    • Collagen, type XV, alpha 1 antibody
    • Endostatin antibody
    • Endostatin XV antibody
    • FLJ27325 antibody
    • FLJ34914 antibody
    • FLJ38566 antibody
    • KNO antibody
    • KNO1 antibody
    • KS antibody
    • MGC74745 antibody
    • Multi functional protein MFP antibody
    • OTTHUMP00000021782 antibody
    • OTTHUMP00000115472 antibody
    • OTTHUMP00000115473 antibody
    see all

Anti-Endostatin antibody [KT58] images

  • ab114141, capturing Human Endostatin in a Sandwich ELISA.
    ab114141 was used at 5 µg/ml to coat the ELISA plates.
    Detection utilised ab106491, which is an IgG2a monoclonal antibody conjugated to HRP.

References for Anti-Endostatin antibody [KT58] (ab114141)

ab114141 has not yet been referenced specifically in any publications.

Product Wall

I am very sorry for the delayed answer. I can now confirm that ab106491 has been tested and is guaranteed to work with ab114141 as an sandwich ELISA pair. The datasheet for ab114141 can be found following this link: Click here (...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"