Overview

  • Product nameAnti-Endothelin 3 antibody
    See all Endothelin 3 primary antibodies
  • Description
    Mouse monoclonal to Endothelin 3
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-239 of Human Endothelin 3

Properties

Applications

Our Abpromise guarantee covers the use of ab54952 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionEndothelins are endothelium-derived vasoconstrictor peptides.
    • Tissue specificityExpressed in trophoblasts and placental stem villi vessels, but not in cultured placental smooth muscle cells.
    • Involvement in diseaseDefects in EDN3 are the cause of Hirschsprung disease type 4 (HSCR4) [MIM:613712]; also known as aganglionic megacolon (MGC). A genetic disorder of neural crest development characterized by the absence of intramural ganglion cells in the hindgut; often resulting in intestinal obstruction.
      Defects in EDN3 are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia.
      Defects in EDN3 are a cause of Waardenburg syndrome type 4 (WS4B) [MIM:613265]; also known as Waardenburg-Shah syndrome. WS4B is characterized by the association of Waardenburg features (depigmentation and deafness) and the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease).
    • Sequence similaritiesBelongs to the endothelin/sarafotoxin family.
    • Cellular localizationSecreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • EDN3 antibody
      • EDN3_HUMAN antibody
      • Endothelin-3 antibody
      • ET 3 antibody
      • ET-3 antibody
      • PPET3 antibody
      • Preproendothelin 3 antibody
      • Preproendothelin-3 antibody
      see all

    Anti-Endothelin 3 antibody images



    • Predicted band size : 25 kDa
      Endothelin 3 antibody (ab54952) at 1ug/lane + LNCaP cell lysate at 25ug/lane.

    References for Anti-Endothelin 3 antibody (ab54952)

    ab54952 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"