Overview

  • Product nameAnti-Endothelin 3 antibody
    See all Endothelin 3 primary antibodies
  • Description
    Rabbit polyclonal to Endothelin 3
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment containing a sequence corresponding to a region within amino acids 1-187 of Human Endothelin 3 (AAH08876).

  • Positive control
    • Raji whole cell lysate; 293T, A431, H1299, HeLa, HepG2 and Molt-4 cell lysates

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab96709 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 25 kDa.

Target

  • FunctionEndothelins are endothelium-derived vasoconstrictor peptides.
  • Tissue specificityExpressed in trophoblasts and placental stem villi vessels, but not in cultured placental smooth muscle cells.
  • Involvement in diseaseDefects in EDN3 are the cause of Hirschsprung disease type 4 (HSCR4) [MIM:613712]; also known as aganglionic megacolon (MGC). A genetic disorder of neural crest development characterized by the absence of intramural ganglion cells in the hindgut; often resulting in intestinal obstruction.
    Defects in EDN3 are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia.
    Defects in EDN3 are a cause of Waardenburg syndrome type 4 (WS4B) [MIM:613265]; also known as Waardenburg-Shah syndrome. WS4B is characterized by the association of Waardenburg features (depigmentation and deafness) and the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease).
  • Sequence similaritiesBelongs to the endothelin/sarafotoxin family.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • EDN3 antibody
    • EDN3_HUMAN antibody
    • Endothelin-3 antibody
    • ET 3 antibody
    • ET-3 antibody
    • PPET3 antibody
    • Preproendothelin 3 antibody
    • Preproendothelin-3 antibody
    see all

Anti-Endothelin 3 antibody images

  • Anti-Endothelin 3 antibody (ab96709) at 1/1000 dilution + Raji whole cell lysate at 30 µg

    Predicted band size : 25 kDa

References for Anti-Endothelin 3 antibody (ab96709)

This product has been referenced in:
  • Liu Y  et al. Autocrine endothelin-3/endothelin receptor B signaling maintains cellular and molecular properties of glioblastoma stem cells. Mol Cancer Res 9:1668-85 (2011). Read more (PubMed: 22013079) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab96709.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"