Overview

  • Product name
    Anti-Endothelin 3 antibody
    See all Endothelin 3 primary antibodies
  • Description
    Rabbit polyclonal to Endothelin 3
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment containing a sequence corresponding to a region within amino acids 1-187 of Human Endothelin 3 (AAH08876).

  • Positive control
    • Raji whole cell lysate; 293T, A431, H1299, HeLa, HepG2 and Molt-4 cell lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab96709 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 25 kDa.

Target

  • Function
    Endothelins are endothelium-derived vasoconstrictor peptides.
  • Tissue specificity
    Expressed in trophoblasts and placental stem villi vessels, but not in cultured placental smooth muscle cells.
  • Involvement in disease
    Defects in EDN3 are the cause of Hirschsprung disease type 4 (HSCR4) [MIM:613712]; also known as aganglionic megacolon (MGC). A genetic disorder of neural crest development characterized by the absence of intramural ganglion cells in the hindgut; often resulting in intestinal obstruction.
    Defects in EDN3 are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia.
    Defects in EDN3 are a cause of Waardenburg syndrome type 4 (WS4B) [MIM:613265]; also known as Waardenburg-Shah syndrome. WS4B is characterized by the association of Waardenburg features (depigmentation and deafness) and the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease).
  • Sequence similarities
    Belongs to the endothelin/sarafotoxin family.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • EDN3 antibody
    • EDN3_HUMAN antibody
    • Endothelin-3 antibody
    • ET 3 antibody
    • ET-3 antibody
    • PPET3 antibody
    • Preproendothelin 3 antibody
    • Preproendothelin-3 antibody
    see all

Images

  • Anti-Endothelin 3 antibody (ab96709) at 1/1000 dilution + Raji whole cell lysate at 30 µg

    Predicted band size : 25 kDa

References

This product has been referenced in:
  • Liu Y  et al. Autocrine endothelin-3/endothelin receptor B signaling maintains cellular and molecular properties of glioblastoma stem cells. Mol Cancer Res 9:1668-85 (2011). Read more (PubMed: 22013079) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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