Overview

  • Product nameAnti-Endothelin A Receptor antibody
    See all Endothelin A Receptor primary antibodies
  • Description
    Sheep polyclonal to Endothelin A Receptor
  • Tested applicationsSuitable for: WB, ELISA, IP, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Sheep, Human
    Predicted to work with: Cow
  • Immunogen

    Synthetic peptide:

    QEQNHNTERSSHK

    conjugated to KLH, corresponding to C terminal amino acids 410-422 of Rat Endothelin A Receptor

  • Positive control
    • Endothelin A receptor transfected COS cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab30536 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration.
ELISA Use at an assay dependent concentration.
IP Use at an assay dependent concentration.
IHC-P Use at an assay dependent concentration.

Target

  • FunctionReceptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
  • Tissue specificityIsoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels.
  • Sequence similaritiesBelongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.
  • Cellular localizationCell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Ednra antibody
    • EDNRA_HUMAN antibody
    • Endothelin 1 receptor precursor antibody
    • Endothelin 1 specific receptor antibody
    • Endothelin A receptor antibody
    • Endothelin ET A receptor antibody
    • Endothelin receptor ET1 specific type antibody
    • Endothelin receptor subtype A antibody
    • Endothelin receptor type A antibody
    • Endothelin-1 receptor antibody
    • ET A antibody
    • ET-A antibody
    • ETA antibody
    • ETA R antibody
    • ETA-R antibody
    • ETAR antibody
    • ETRA antibody
    • hET AR antibody
    • hET-AR antibody
    see all

References for Anti-Endothelin A Receptor antibody (ab30536)

This product has been referenced in:
  • Riemekasten G  et al. Involvement of functional autoantibodies against vascular receptors in systemic sclerosis. Ann Rheum Dis 70:530-6 (2011). WB ; Human . Read more (PubMed: 21081526) »

See 1 Publication for this product

Product Wall

Thank you for contacting us. At this time we do not offer the blocking peptide forthese products. However the immunogen sequences of both products are available on our website. You may be able to have custom peptide created from these for use as a bloc...

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Thank you for your enquiry. Unfortunately, we do not have the IHC image available. However, the we do have the protocols as below. IHC-Paraffin (Tissue section: lung and intestine) Fixed paraffin-embedded sections (4-6 mm) are deparaffinized...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"