Overview

  • Product name
  • Description
    Rabbit polyclonal to ENO3
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide conjugated to KLH, surrounding amino acids 49-53 (L-R-D-G-D) of Human ENO3.

  • Positive control
    • 3T3, HepG2 and C2C12 cell extracts.

Properties

Applications

Our Abpromise guarantee covers the use of ab119327 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 47 kDa.

Target

  • Function
    Appears to have a function in striated muscle development and regeneration.
  • Tissue specificity
    The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.
  • Pathway
    Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.
  • Involvement in disease
    Defects in ENO3 are the cause of glycogen storage disease type 13 (GSD13) [MIM:612932]. A metabolic disorder that results in exercise-induced myalgias, generalized muscle weakness and fatigability. It is characterized by increased serum creatine kinase and decreased enolase 3 activity. Dramatically reduced protein levels with focal sarcoplasmic accumulation of glycogen-beta particles are detected on ultrastructural analysis.
  • Sequence similarities
    Belongs to the enolase family.
  • Developmental stage
    During ontogenesis, there is a transition from the alpha/alpha homodimer to the alpha/beta heterodimer in striated muscle cells, and to the alpha/gamma heterodimer in nerve cells.
  • Cellular localization
    Cytoplasm. Localized to the Z line. Some colocalization with CKM at M-band.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2 phospho D glycerate hydrol yase antibody
    • 2 phospho D glycerate hydrolyase antibody
    • 2-phospho-D-glycerate hydro-lyase antibody
    • Beta enolase antibody
    • Beta-enolase antibody
    • ENO3 antibody
    • ENOB_HUMAN antibody
    • Enolase 3 (beta muscle) antibody
    • Enolase 3 antibody
    • Enolase3 antibody
    • GSD13 antibody
    • MSE antibody
    • Muscle specific enolase antibody
    • Muscle-specific enolase antibody
    • Skeletal muscle enolase antibody
    see all

Images

  • All lanes : Anti-ENO3 antibody (ab119327) at 1/500 dilution

    Lane 1 : 3T3 cell extract
    Lane 2 : HepG2 cell extract
    Lane 3 : C2C12 cell extract


    Predicted band size : 47 kDa

References

ab119327 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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