Overview

  • Product nameAnti-ENPP3 antibody [NP4D6]
    See all ENPP3 primary antibodies
  • Description
    Mouse monoclonal [NP4D6] to ENPP3
  • SpecificityThe mouse monoclonal antibody NP4D6 reacts with CD203c, a transmembrane ectoenzyme expressed on basophils and mast cells, and overexpressed upon their activation.
  • Tested applicationsSuitable for: ICC/IF, IHC-Fr, Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    HEK-293 cells transfected with Human ENPP3

Properties

Applications

Our Abpromise guarantee covers the use of ab90754 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use at an assay dependent concentration.
IHC-Fr 1/100. PubMed: 23225236
Flow Cyt Use a concentration of 1 - 5 µg/ml. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Target

  • FunctionCleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and NAD.
  • Tissue specificityExpressed in bile ducts, prostate, uterus and colon. Exclusively expressed on basophils, mast cells and their progenitors.
  • Sequence similaritiesBelongs to the nucleotide pyrophosphatase/phosphodiesterase family.
    Contains 2 SMB (somatomedin-B) domains.
  • Post-translational
    modifications
    N-glycosylation is necessary for correct trafficking to the apical surface, but is not the apical targeting signal.
    It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
  • Cellular localizationMembrane. Secreted. Located to the apical surface in intestinal and kidney epithelial cells. Located to the cell surface of basophils, and to the apical plasma membrane of bile duct cells. Secreted in serum, and in lumen of epithelial cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • Alkaline phosphodiesterase I antibody
    • ARHR2 antibody
    • B10 antibody
    • CD203c antibody
    • CD203c antigen antibody
    • dJ1005H11.3 (phosphodiesterase I/nucleotide pyrophosphatase 3) antibody
    • dJ914N13.3 (phosphodiesterase I/nucleotide pyrophosphatase 3) antibody
    • E NPP 3 antibody
    • E-NPP 3 antibody
    • Ectonucleotide pyrophosphatase/phosphodiesterase 3 antibody
    • Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 antibody
    • ENPP3 antibody
    • ENPP3_HUMAN antibody
    • gp130RB13 6 antibody
    • gp130RB136 antibody
    • M6S1 antibody
    • NPP1 antibody
    • NPP3 antibody
    • NPPase antibody
    • NPPS antibody
    • Nucleotide pyrophosphatase antibody
    • PC-1 antibody
    • PCA1 antibody
    • PD Ibeta antibody
    • PD-Ibeta antibody
    • PDNP1 antibody
    • PDNP3 antibody
    • Phosphodiesterase I beta antibody
    • Phosphodiesterase I/nucleotide pyrophosphatase 3 antibody
    • phosphodiesterase i/nucleotide pyrophosphatase beta antibody
    see all

References for Anti-ENPP3 antibody [NP4D6] (ab90754)

This product has been referenced in:
  • Aliagas E  et al. Ecto-nucleotidases distribution in human cyclic and postmenopausic endometrium. Purinergic Signal 9:227-37 (2013). IHC-Fr ; Human . Read more (PubMed: 23225236) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab90754.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"