Overview

  • Product name
  • Description
    Rabbit polyclonal to ENSA
  • Tested applications
    Suitable for: WB, ICCmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-102 of Human ENSA (NP_004427).

  • Positive control
    • A549 whole cell lysate HeLa whole cell lysate HCT116 whole cell lysate HeLa cells (methanol fixed)

Properties

Applications

Our Abpromise guarantee covers the use of ab125873 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 13 kDa.
ICC 1/100 - 1/500.

Target

  • Relevance
    ENSA (Alpha endosulfine) is expressed in a wide range of tissues including muscle, brain, and endocrine tissues. The recombinant protein inhibits binding of labeled glibenclamide to beta cell membranes. It also inhibits cloned K(ATP) channel currents and thereby stimulates insulin secretion. It was proposed that endosulfine is an endogenous regulator of the K(ATP) channel, which has a key role in the control of insulin release and, more generally, couples cell metabolism to electrical activity.
  • Cellular localization
    Cytoplasmic
  • Database links
  • Alternative names
    • Alpha endosulfine antibody
    • ARPP 19e antibody
    • Endosulfine alpha antibody

Images

  • Anti-ENSA antibody (ab125873) at 1/1000 dilution + A549 whole cell lysate at 30 µg

    Predicted band size : 13 kDa
    15% SDS PAGE
  • Methanol-fixed HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for ENSA (green) using ab125873 at 1/500 dilution in ICC/IF. Blue: Hoechst 33343 staining.

References

ab125873 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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