The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notesWB: Use at a concentration of 1-5 µg/ml.
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
FunctionResponsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.
Tissue specificityIntestinal brush border.
Involvement in diseaseDefects in TMPRSS15 are a cause of enterokinase deficiency (ENTKD) [MIM:226200]; a life-threatening intestinal malabsorption disorder characterized by diarrhea and failure to thrive.
Sequence similaritiesBelongs to the peptidase S1 family. Contains 2 CUB domains. Contains 2 LDL-receptor class A domains. Contains 1 MAM domain. Contains 1 peptidase S1 domain. Contains 1 SEA domain. Contains 1 SRCR domain.
Post-translational modificationsThe chains are derived from a single precursor that is cleaved by a trypsin-like protease.