FunctionResponsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.
Tissue specificityIntestinal brush border.
Involvement in diseaseDefects in TMPRSS15 are a cause of enterokinase deficiency (ENTKD) [MIM:226200]; a life-threatening intestinal malabsorption disorder characterized by diarrhea and failure to thrive.
Sequence similaritiesBelongs to the peptidase S1 family. Contains 2 CUB domains. Contains 2 LDL-receptor class A domains. Contains 1 MAM domain. Contains 1 peptidase S1 domain. Contains 1 SEA domain. Contains 1 SRCR domain.
Post-translational modificationsThe chains are derived from a single precursor that is cleaved by a trypsin-like protease.